Unilever Patent Holdings B.v.

Quest International B.v.

Internationale Octrooi Maatschappij 'octropa' Bv

Conopco, Inc.

Lipton, Division of Conopco, Inc.

Vhsquared Limited

Internationale Otrool Maatschappij 'octropa' B.v.

Adrianus M Ledeboer

Cornelis T Verrips

Jan Maat

Luppo Edens

Jan Kok

Gerard Venema

Robert Vreeker

Cornelis P Hollenberg

Zbigniew A Janowicz

Christiaan Visser

Leon Gerardus Joseph Frenken

Sandra Bezemer

Steven Howell

Girbe Buist

Janos Bodor

Leon Gerardus Frenken

Cornelis P Van Der Logt

Jan Kuiper

Johannes A Van Den Berg

Yvon Maria Ijsseldijk

Jan Cornelis De Smit

Lars-Gõran Lennart Hammarström

Marinus Theodorus Pleijsier

Arjan Nauta

Jan W Sanders

Johannes Joseph Wilhelmus De Haard

Robert Klok

Gerard Willem Robijn

Leo Gerardus Joseph Frenken

Johannes Joseph Wilhelmus deHaard

Dirk Johannes Van Den Berg

The present invention relates to heavy chain immunoglobulins or fragments thereof of the VHH or VNAR type, or domain antibodies (dAbs) of the heavy or light chains of immunoglobulins or fragments thereof, suitable for use in the management of infections, in particular of the gastrointestinal tract. The present invention also relates to a delivery system comprising these heavy chain immunoglobulins or functional fragments thereof of the VHH or VNAR type, or domain antibodies (dAbs) of the heavy or light chains of immunoglobulins or fragments thereof, and hosts comprising expression vectors encoding for these heavy chain immunoglobulins or functional fragments thereof of the VHH or VNAR type, or domain antibodies (dAbs) of the heavy or light chains of immunoglobulins or fragments thereof. The invention also relates to food products and pharmaceutical preparations comprising the delivery system, and methods for the preparation of food products according to the invention.

Heavy chain and single domain antibodies

A method of inhibiting viral infection using a monovalent antigen binding protein comprising a single domain binding unit capable of binding to a virus is described. Preferably the protein is a heavy chain variable domain derived from an immunoglobulin naturally devoid of light chains. Food, pharmaceutical and cosmetic products comprising such proteins are also described together with a method for selecting inhibiting proteins from a large population of mainly containing non-inhibiting, but infectious agent binding fragments.

Inhibition of viral infection using antigen-binding proteins

A multivalent antigen binding protein comprises a single polypeptide chain comprising, in series, two or more single domain binding units which are preferably heavy chain variable domains derived from an immunoglobulin naturally devoid of light chains. Methods for their production and uses thereof, in particular for diagnosis, immunoassay and purification methods are disclosed.

Multivalent antigen-binding proteins

Dairy spreads, especially fresh cheese, are sensitive for heat treatments. The heat treated products are often grainy, mealy and chalky. The invention relates to a method of producing a dairy spread wherein a cheese milk or cream or a combination thereof is acid coagulated in the presence of a suitable culture, wherein the culture comprises an exopolysaccharide producing lactic acid bacterium capable of reducing the graininess of the heat treated dairy spread.

Method of preparing a dairy spread

Complex inducible promoter system derivable from a phage of a lactic

Salt-inducible promoter derivable from a lactic acid bacterium, and its

Process for the lysis of a culture of lactic acid bacteria by means of a

Lactobacillus sake like strains, production and use of their

The structural genes and their regulatory DNA sequences of an alcohol oxidase (MOX) and a dihydroxyacetone synthase (DHAS) of Hansenula polymorpha have been isolated and the nucleotide sequences determined. The invention relates to the use of the MOX gene, as well as the use of the regulatory DNA sequences of MOX and/or DAS in combination with the MOX gene, optionally after modification thereof, or other oxidase genes, or other genes, to produce engineered microorganisms, 0in particular yeasts. Said engineered microorganisms can produce oxidases or other enzymes in yields that allow industrial application on a large scale. Moreover, said engineered microorganisms can produce oxidases having improved properties with respect to their application in oxidation reactions and/or in bleaching and detergent products.

Expression and production of polypeptides using the promoters of the

The structural genes and their regulatory DNA sequences of an alcohol oxidase (MOX) and a dihydroxyacetone synthase (DHAS) of Hansenula polymorpha have been isolated and the nucleotide sequences determined. The invention relates to the use of the MOX gene, as well as the use of the regulatory DNA sequences of MOX and/or DAS in combination with the MOX gene, optionally after modification thereof, or other oxidase genes, or other genes, to produce engineered microorganisms, in particular yeasts. Said engineered microorganisms can produce oxidases or other enzymes in yields that allow industrial application on a large scale. Moreover, said engineered microorganisms can produce oxidases having improved properties with respect to their application in oxidation reactions and/or in bleaching and detergent products.

Regulatory sequences of alcohol oxidase (MOX) and

The invention relates to structural genes consisting of DNA sequences encoding non-processed and partly processed thaumatin, to the various allelic forms of said non-processed thaumatin and to recombinant DNA's and plasmids comprising said structural genes coding for the various allelic forms of preprothaumatin, and naturally and/or artificially modified preprothaumatin in various stages of its natural processing, and to the use of said recombinant plasmids to transform microorganisms, particularly bacteria in which said genes are expressed.

Structural genes encoding the various allelic and maturation forms of

The invention relates to DNA sequences encoding the various allelic forms of mature thaumatin, and cloning vehicles comprising said DNA sequences and their use in transforming microorganisms.

DNA sequences encoding the various allelic forms of mature thaumatin,

The invention relates to structural genes comprising encoding non-processed and partly processed thaumatin, to the various allelic forms of said non-processed thaumatin and to recombinant DNA's and plasmids comprising said structural genes coding for the various allelic forms of preprothaumatin, and naturally and/or artifically modified preprothaumatin in various stages of its natural processing, and to the use of said recombinant plasmids to transform microorganisms, particularly bacteria in which said genes are expressed.

Yeast of the genus kluyveromyces modified for the expression of

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Rotterdam, Netherlands

Adrianus M Ledeboer