Regeneron Pharmaceuticals, Inc.

Regeneran Pharmaceuticals, Inc.

Adrianna Latuszek

Ying Hu

Andrew J Murphy

Alexander O Mujica

Stanley J Wiegand

Jingtai Cao

William C Olson

Carmelo Romano

Lynn Macdonald

John R McWhirter

Karolina Meagher

John Mcwhirter

Alexander Mujica

Stanley Wiegand

Andrew Murphy

The present invention provides monoclonal antibodies that bind to the complement factor 5 (C5) protein, and methods of use thereof. In various embodiments of the invention, the antibodies are fully human antibodies that bind to C5 protein. In some embodiments, the antibodies of the invention are useful for inhibiting or neutralizing C5 activity, thus providing a means of treating or preventing a C5-related disease or disorder in humans. In some embodiments, the invention provides for an anti-C5 antibody that has improved pharmacokinetic and pharmacodynamic properties, e.g., a half-life of more than 10 days.

Polynucleotides encoding anti-C5 antibodies

Methods of treating C5-associated diseases comprising administering anti-C5 antibodies

Non-human animals comprising a human or humanized C3 and/or C5 nucleic acid sequence are provided as well as methods for using the same to identify compounds capable of modulating the complement system. Non-human animals that comprise a replacement of the endogenous C5 gene and/or C3 gene with a human or humanized C5 gene and/or C3 gene, and methods for making and using the non-human animals, are described. Non-human animals comprising a human or humanized C5 gene under control of non-human C5 regulatory elements is also provided, including non-human animals that have a replacement of non-human C5-encoding sequence with human C5-encoding sequence at an endogenous non-human C5 locus. Non-human animals comprising a human or humanized C3 gene under control of non-human C3 regulatory elements is also provided, including non-human animals that have a replacement of non-human C3 protein-encoding sequence with human or humanized C3 protein-encoding sequence at an endogenous non-human C3 locus. Non-human animals comprising human or humanized C3 and/or C5 sequences, wherein the non-human animals are rodents, e.g., mice or rats, are provided.

Humanized C5 animals

Anti-C5 antibodies

Humanized C3 animals

Growing community of inventors

Sleepy Hollow, NY, United States of America

Adrianna Latuszek