Scholar Rock, Inc.

Children's Medical Center Corporation

Children's Medical Center Coporation

Adriana Donovan

Michelle Marie Straub

Stefan Wawersik

Leonard I Zon

Gregory John Carven

Katherine Jane Turner

Yung Chyung

Justin W Jackson

Abhishek Datta

Kimberly Kafadar Long

Allan Capili

Kevin B Dagbay

John Bukowski

Kevin Schutz

Micah Webster

Samantha Nicholls

Meghan McDonald

Lorena Lerner

Leonard Ira Zon

Selective inhibitors of repulsive guidance molecule C (RGMc), are described. Related methods, including methods for making, as well as therapeutic use of these inhibitors in the treatment of disorders, such as anemia, are also provided.

RGMC-selective inhibitors and use thereof

The present invention relates to antibodies that specifically bind pro-myostatin and/or latent myostatin, and methods and uses thereof.

Methods for altering body composition by administering anti-pro/latent myostatin antibodies

Aspects of the present disclosure relate to antibodies that specifically bind proMyostatin and/or latent Myostatin and uses thereof.

Methods for using anti-myostatin antibodies

The present invention relates to antibodies, or antigen-binding fragments thereof, that specifically bind proMyostatin and/or latent Myostatin, and methods and uses thereof for treating metabolic diseases.

Compositions and methods for making and using anti-myostatin antibodies

The present disclosure relates to the treatment of muscle conditions, such as SMA, with the use of an agent that inhibits myostatin signaling. The disclosure includes combination therapies that include a myostatin inhibitor and a neuronal corrector.

Use of myostatin inhibitors and combination therapies

Methods for inhibiting myostatin activation by administering anti-pro/latent myostatin antibodies

Anti-pro/latent-Myostatin antibodies and uses thereof

Positional cloning has been carried out to identify the gene responsible for the hypochromic anemia of the zebrafish mutant weissherbst. The gene, ferroportin1, encodes a novel multiple-transmembrane domain protein, expressed in the yolk sac. Zebrafish ferroportin1 is required for the transport of iron from maternally-derived yolk stores to the circulation, and functions as an iron exporter when expressed inoocytes. Human and mouse homologs of the ferroportin1 gene have been identified. The invention includes isolated polynucleotides, vectors and host cells comprising nucleotide sequences encoding Ferroportin1 proteins and variants thereof, including those having iron transport function. The invention also includes polypeptides encoded by ferroportin1 genes and variants of such polypeptides, and fusion polypeptides comprising a Ferroportin1 or a portion thereof. Methods to produce a Ferroportin1, methods to produce antibodies to a Ferroportin1 and methods to identify agents binding to a Ferroportin1, which can be inhibitors or enhancers of Ferroportin1 iron transport activity, are also described. Inhibitors of Ferroportin1 activity can be used in a therapy for hemochromatosis.

Ferroportin1 nucleic acids, proteins, antibodies and methods

Ferroportin1 antibodies and methods

Ferroportin1 nucleic acids and proteins

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West Roxbury, MA, United States of America

Adriana Donovan