Howmedica Osteonics Corporation

Howmedica Leibinger Inc.

Adrian Sun Wai

Donal O'Mahony

Brian J Hess

Paul Higham

Gerard M Insley

Matthew E Murphy

Venkat R Garigapati

Joseph P Zitelli

Sandra M Murray

Donal O'mahony

The present invention relates to a bone cement precursor system that is presented in the form of two shelf-stable pastes which have been terminally sterilized and are held in separate containers during product transport and storage. When the product is used during surgery, these pastes inject to a site of application through a static mixing device by the action of applied injection force. When the two pastes are mixed, they start to react to each other while injecting out. The resulting composition is highly biocompatible, osteoconductive, injectable, rapid setting and bioresorbable, and is useful in connection with bone repair procedures, for example, in the craniomaxillofacial, trauma and orthopedic areas.

Post irradiation shelf-stable dual paste direct injectable bone cement precursor systems and methods of making same

The invention is related to a premixed putty calcium phosphate composition comprising at least two calcium phosphate minerals, at least one reaction retarding agent, at least one binding agent, at least one sodium phosphate, and at least one nonaqueous extender, wherein one of said at least two calcium phosphate minerals contains a stabilizing agent.

Injectable calcium phosphate cement

A calcium phosphate composition comprising at least one calcium phosphate mineral, at least one reaction retarding agent, at least one biding agent, and at least one sodium phosphate compound.

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Limerick, Ireland

Adrian Sun Wai