Iceutica Pty Ltd.

Iceutica Py Ltd.

Iceutica Holdings Inc.

Adrian Russell

H William Bosch

Felix Meiser

Marck Norret

Aaron Dodd

Matthew Callahan

The present invention relates to methods for producing particles of indomethacin using dry milling processes as well as compositions comprising indomethacin, medicaments produced using indomethacin in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of indomethacin administered by way of said medicaments.

Formulation of indomethacin

Methods for making inhalable composite particles comprising a pharmaceutically-active agent, the method comprising: a) providing composite particles comprising a millable grinding matrix and a solid pharmaceutically-active agent, wherein the pharmaceutically-active agent has an median particle size on a volume average basis between 50 nm and 3 &#x3bc;m; and b) milling the composite particles in a mill without milling bodies for a time period sufficient to produce inhalable composite particles having a mass median aerodynamic diameter between 1 &#x3bc;m and 20 &#x3bc;m are described.

Inhalable pharmaceutical compositions

The present invention relates to methods for producing particles of diclofenac using dry milling processes as well as compositions comprising diclofenac, medicaments produced using diclofenac in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of diclofenac administered by way of said medicaments.

Formulation of diclofenac

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Rivervale, Australia

Adrian Russell