The University of Texas System

Adrian Recinos

Allan R Brasier

John E Wiktorowicz

Hyunsu Ju

Heidi Spratt

Tadeusz Kochel

Nikos Vasilakis

Eduardo Nascimento

Ernesto E T Marquez

Josefina Nores Garcia

Marli Tenorio

Laura H V G Gil

The present invention provides compositions and methods for detecting, analyzing, and identifying biomolecules used to diagnose patient with risk of DHF. More particularly, the invention provides plasma biomarkers including complement factor D to complement factor H (FactorD/FactorH) ratio and levels of one or more of IL2, desmoplakin, and high molecular weight albumin, which are used to detect risk of developing DHF.

Method and biomarkers for the detection of dengue hemorrhagic fever

The present invention provides methods for detecting, analyzing, and identifying biomolecules used to identifying patient with dengue-like symptom who are at risk of DHF. The inventive method comprises detecting in a sample from a subject dengue infected patient one or more biomarkers selected from the group consisting of IL-10, fibrinogen, C4A, immunoglobulin, tropomyosin, and three isoforms of albumin, and which are used in a predictive MARS model to detect patients with risk of developing DHF.

Methods and biomarkers for the detection of dengue hemorrhagic fever

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Galveston, TX, United States of America

Adrian Recinos