Evonik Corporation

Surmodics Pharmaceuticals, Inc.

Adrian Raiche

Gary W Opperman

Bruce W Hudson

Jason Campbell

Heather Nettles

Brandon Smith

Allison Womack

Kehley Miller

The present disclosure relates to processes for preparing microparticles using an emulsion process where both a solvent and a salt are used in the continuous phase of the emulsion. The present disclosure also relates to microparticles having an angle of repose of &#x2264;35, as measured using a Hele-Shaw cell.

Microencapsulation process with solvent and salt

Disclosed herein are apparatus and methods for producing emulsions, and, in particular, for maintaining laminar flow during production of emulsions containing microsuspensions. Disclosed herein are columns for receiving a packing material that permits fluid flow through the column. The columns have a periphery that defines an interior cavity in fluid communication with inlets and outlets of the column. Disclosed herein is a method of preparing an emulsion that includes (1) forming a first phase typically containing an organic solvent, a polymer, and one or more biologically active agents and/or chemicals; (2) forming a second phase typically containing water as the second solvent, an emulsion stabilizer and optionally a solvent; and (3) passing the first and the second phases through the column to form a 'water in oil' type emulsion.

Apparatus and methods for preparing an emulsion

The disclosed process comprises freeze-drying a biodegradable implant device comprised or one or more polyesters to thereby reduce moisture content in the device.

Process for reducing moisture in a biodegradable implant device

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Helena, AL, United States of America

Adrian Raiche