Genera Technologies Limited

Other

Scientific Generics Limited

Severn Trent Water Limited

Adrian Parton

Xiao-Bo Wang

Ying Chi Huang

Denise V Pollard-Knight

Alastair R MacGregor

Ronald Pethig

Methods of capturing and labeling a species, include attracting magnetically attractable particles to a solid support by magnetic forces, which particles have an affinity for the species, contacting the particles on the support with a sample containing the species to capture the species onto the particles on the support, and binding the species captured on the particles directly or indirectly to a detectable label before and/or whilst the species is captured on the particles on the support. The label may be bound to the captured species via an immunological binding partner which binds selectively to the species and may be a fluorescent label, luminescent label, enzyme label, dye label, phosphorescent label, metal-chelating label, radio label, spin label, heavy metal label, nucleic acid or nucleic acid analog hybridization label, avid or avid-like label suitably bound to or incorporated in particles which also bear a binding agent such as an antibody causing the particles to bind to the captured species.

Methods of capture and assay procedures

Particles are subjected to travelling wave field migration (TWFM) to migrate the particles over an array of microelectrodes. Altered particles are produced by treating original particles in such a way so as to alter their TWFM characteristics and the altered TWFM characteristics are employed for analysis and/or separation of the altered particles. The particles may be cells, bacteria, viruses, biomolecules or plastics microspheres. They may be altered by binding to a ligand such as a metal microparticle via a selective linking moiety such as an antibody/antigen or oligonucleic acid, or be physical or chemical treatments.

Methods of analysis/separation

A method and apparatus for filtering microorganisms from a sample and culturing the microorganisms employs a membrane filter (3) in a filter holder (10) in which holder the membrane filter is supported on an absorbent support (26) which is maintained in an expansible compressed state against the membrane filter so that any expansion of the membrane filter when wetted by a sample does not cause bubbling of the membrane filter away from its support entrapping air bubbles and so preventing supply of nutrient from culture medium supplied to the support from reaching the microorganisms on the membrane filter.

Filtration and culture methods and apparatus

Methods of capturing species from liquids and assay procedures

Filtration method and apparatus

Growing community of inventors

Exning, United Kingdom

Adrian Parton