Corium International, Inc.

A.v. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences

Ranir, LLC

Corium Corporation

Schering-plough Healthcare Products Inc.

A.v. Topchiey Institute of Petrochemical Synthesis, Russian Academy of Sciences

A.v. Topchiev Institute of Petrochemical Synthesis

Adrian Faasse

Parminder Singh

Gary Wynn Cleary

Mikhail M Feldstein

Sri Mudumba

Danir F Bayramov

Sreenivasu Mudumba

Charles E Lundy

Steven Richard Klemm

Ashutosh Shastry

Danir F Bairamov

Michael G Marcoux

Danir R Bairamov

Danir Bairamov

Christopher D Bryan

Glen Edward Groeneweg

Joseph C Townshend

Alan Gene Thelen

Janet Lai

Emilie S Beskar

Michael P Willison

Devices and methods for manufacturing and using microstructure arrays are described. In the methods, formulation is introduced into cavities of a microprojection array mold by means that include a vacuum to achieve a more efficient and uniform filling of the cavities and/or reduce bubble formation in the cavities.

Microarray for delivery of therapeutic agent, methods of use, and methods of making

A composition is provided, wherein the composition comprises a water-swellable, water-insoluble polymer, a blend of a hydrophilic polymer with a complementary oligomer capable of hydrogen or electrostatic bonding to the hydrophilic polymer. The composition also includes a backing member. Active ingredients, such as a whitening agent, may be included. The composition finds utility as an oral dressing, for example, a tooth whitening composition that is applied to the teeth in need of whitening. The composition can be designed to be removed when the degree of whitening has been achieved or left in place and allowed to erode entirely. In certain embodiments, the composition is translucent. Methods for preparing and using the compositions are also disclosed.

Hydrogel compositions with an erodible backing member

An oral care agent delivery device is provided which comprises a permanently deformable backing layer, an anchor layer overtop the backing layer, and an oral care layer overtop the anchor layer. The device is sized to fit over a plurality of teeth in an upper or lower dental arch of a subject. The oral care layer comprises at least one oral care agent and at least one hydrophilic polymer. The oral care layer is in contact with the anchor layer and forms an adhesive bond with the anchor layer; however, the oral care layer is minimally invested in the anchoring layer. When hydrated, the oral care layer has an adhesiveness relative to the surface of a user's teeth that is sufficient to retain the device on the user's teeth when placed thereon. The device can also have an oral care agent which is activated on hydration of the oral care layer, or an oral care layer which releases the oral care agent over time.

Device and method for delivering an oral care agent

An oral care agent delivery device is provided which comprises a permanently deformable backing layer, an oral care layer, and a non-woven binding material with a first part that is substantially invested in the oral care layer and a second part that is substantially invested in the backing layer. The device is sized to fit over a plurality of teeth in an upper or lower dental arch of a subject. The oral care layer comprises at least one oral care agent and at least one hydrophilic polymer. When hydrated, the oral care layer has an adhesiveness relative to the surface of a user's teeth that is sufficient to retain the device on the user's teeth when placed thereon. The device can also have an oral care agent which is activated on hydration of the oral care layer, or an oral care layer which releases the oral care agent over time.

A dermal, transdermal, mucosal or transmucosal delivery device is provided. The device includes a backing layer, defining an ingredient containing reservoir, a cover for the reservoir having at least one opening therethrough, an adhesive layer and a liner layer. Upon removal of the liner layer, the device may be placed over the desired area of the skin or mucosa and adhesively applied thereto allowing the ingredients to flow from the reservoir through the at least one opening to the dermis or mucosa.

Dermal, transdermal, mucosal or transmucosal ingredient delivery devices

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Carmel Valley, CA, United States of America

Adrian Faasse