Inhale Therapeutic Systems, Inc.

Pearl Therapeutics, Inc.

Nektar Therapeutics

Novartis Pharma Ag

Germitec

Novartis Ag

Germitec Sa

Bgp Products Operations Gmbh

Inhale Therapeutics Systems, Inc.

Pearl Thereapeutics, Inc.

At&t Wireless Services, Inc.

Ph&t S.p.a.

Adrian Edward Smith

Gregory Walter Hall

John D Burr

George S Axford

Derrick J Parks

Reinhard Vehring

Michael Steven Hartman

Vidya B Joshi

Sarvajna Kumar Dwivedi

Carlos A Schuler

Kyle A Naydo

Michael J Rocchio

Dennis E Wightman

Jeffrey Wayne Etter

David Lechuga-Ballesteros

Frédéric Lepine

Clément Deshays

Randy Kent Hall

Charles Ray

Scot Cheu

Jack M Anthony

Normand Nantel

Cédric Neveu

Herman Snyder

René Deshays

Jamshed Ghandhi

Robert Bruce Chess

Robert M Platz

Ileana A Leuca

John A Howard

William W Alston

Andrew Clark

Kevin S Nason

Herman E Snyder

Steve Paboojian

Fabrizio Niccolai

Shirley W Lyons

Derrick Tuttle

Kevin Russert Walsh

Dennis Rasmussen

Jeff R Wood

Brian R S Ward

Aneesh Bakshi

Sarvajna Jumar Dwivedi

Jeffery W Etter

Herm Snyder

Jamshed Ghandi

Walter Cecka

David William Holmes

Winfield Fisher

Gal Cohen

Kyle Naydo

Derrick J Tuttle

Dennis R Rasmussen

The invention concerns a disinfection device includes a disinfection chamber having an interior volume and a radiation source coupled to the interior volume. The radiation source is arranged to emit disinfecting radiation into the interior volume when in operation. A disinfection program in the disinfection chamber is arranged to control the radiation source to emit the disinfecting radiation according to parameters determined based on at least one of a three dimensional model of the disinfection chamber and a three dimensional model of a target article to be disinfected. The three dimensional model of the disinfection chamber is formed using data collected by operating at least one radiation source in a data collection disinfection chamber, or by providing a disinfection chamber model having a virtual interior volume. The three dimensional model of the target article to be disinfected is formed by providing a target article model having a virtual surface.

Modeling to assist high-level UV-C disinfection

Embodiments are directed towards methods and systems of depositing a uniform test-pathogen mixture onto a test article for testing the sterilization efficacy of an electromagnetic radiation or other sterilization process. The system includes a holding mechanism configured to removably secure the test article to the system. The system also includes a test-pathogen dispenser configured to uniformly deposit the test-pathogen mixture onto a reference surface of the test article. The system is structured so that at least one of the test article and the test-pathogen dispenser moves relative to the other. A plurality of test-pathogen mixture droplets or lines is deposited onto the reference surface in a predetermined test-pathogen pattern, such as, for example, a plurality of rows and columns of droplets. A distance from a dispenser tip of the test-pathogen dispenser to the reference surface of the test article may be determined to help maintain consistency between test-pathogen mixture droplets or lines.

Bioassay carrier and preparation thereof

Compositions, methods and systems are provided for pulmonary delivery of long-acting muscarinic antagonists and long-acting &#x3b2;adrenergic receptor agonists via a metered dose inhaler. In particular embodiments, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium.

Compositions for pulmonary delivery of long-acting muscarinic antagonists or long-acting B2 adrenergic receptor agonists and associated methods and systems

An aerosolization apparatus comprises a body having an inlet, an endpiece having an outlet, the endpiece being connectable to the body to define a chamber, wherein the chamber is sized to receive a capsule containing a pharmaceutical formulation in a manner which allows the capsule to move within the chamber. The apparatus further includes a connection mechanism to provide selective connection of the endpiece to the body, wherein a rotational force between the endpiece and the body is needed to connect or disconnect the endpiece from the body, the rotational force being applied about an axis passing through the chamber. When a user inhales, air enters into the chamber through the inlet so that the pharmaceutical formulation is aerosolized within the chamber and the aerosolized pharmaceutical formulation is delivered to the user through the outlet. The connection mechanism prevents inadvertent disconnection of the endpiece from the body.

Aerosolization apparatus with removable mouthpiece

A disinfection device includes a disinfection chamber into which a radiation source emits ultraviolet-C (UV-C) radiation. A radiation sensor detects the amount of UV-C radiation within the disinfection chamber, and a temperature sensor produces temperature values of a temperature within the disinfection chamber. A processing unit generates accumulated UV-C radiation values and verifies that the accumulated UV-C radiation value in the disinfection chamber reaches a first radiation threshold while also verifying that the temperature in the disinfection chamber stays below a first temperature threshold. The UV-C radiation may be emitted into the disinfection chamber over one or more fixed periods of time while the total time for the disinfection process is limited to a primary time interval. The process may terminate successfully if the first radiation threshold is exceeded before the primary time interval expires. The disinfection device provides high level disinfection of contaminated articles in a short time and at a low temperature.

Methods, systems, and devices for high-level disinfection

Compositions for pulmonary delivery of long-acting muscarinic antagonists and associated methods and systems

Compositions, methods and systems are provided for pulmonary or nasal delivery of two or more active agents via a metered dose inhaler. In one embodiment, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium.

Compositions, methods and systems for respiratory delivery of two or more active agents

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Compositions, methods and propellant-based systems for respiratory delivery of glycopyrrolate and one or more active agents

The invention provides various apparatus and methods for aerosolizing a powdered medicament. In one exemplary embodiment, an apparatus includes a pressurization cylinder, and a piston which is slidable within the cylinder to pressurize a gas. A handle is coupled to the piston and is movable between an extended position and a home position to pressurize the gas. An aerosolizing mechanism is included and is configured to aerosolize a powdered medicament that is held within a receptacle with pressurized gas from the cylinder. A carriage assembly is included to receive the receptacle and to couple the receptacle to the aerosolizing mechanism. A first and a second interlock are operably engageable with the carriage assembly to prevent coupling of the receptacle with the aerosolization mechanism. The first interlock is released to allow movement of the carriage upon movement of the handle to the extended position. The second interlock remains engaged if the receptacle is only partially inserted into the carriage assembly.

Dry powder dispersing apparatus and methods for their use

The invention provides systems and methods for measuring the mass of a substance. In one method, energy is applied to a substance and a response resulting from the application of energy as measured. The mass of the substance is then determined based at least in part on the measured response.

Systems and methods for non-destructive mass sensing

Growing community of inventors

Emerald Hills, CA, United States of America

Adrian Edward Smith