Global Alliance for Tb Drug Development

Auckland Uniservices Limited

Adrian Blaser

William Alexander Denny

Zhenkun Ma

Andrew Mark Thompson

Brian Desmond Palmer

Hamish Scott Sutherland

Iveta Kmentova

Genliang Lu

Charles Z Ding

William Robert Wilson

Ho Huat Lee

Keith D Combrink

Michael Patrick Hay

Bronwyn Gae Siim

Jiancheng Wang

Shangjin Yang

Kevin Owen Hicks

Frederik Bastiaan Pruijn

Karin Pchalek

Dianjun D Chen

Minsoo Song

Andrew M Thompson

Diajun D Chen

The present invention relates to novel nitroimidazooxazines, to their preparation, and to their use as drugs for treatingand other microbial infections, either alone or in combination with other anti-infective treatments.

Nitroimidazooxazines and their uses in anti-tubercular therapy

The current invention pertains to nitroimidazooxazine and nitroimidazooxazole analogues, their methods of preparation, and uses of the compounds as treatment for, for use as anti-tubercular drugs, for use as anti-protozoal agents with unexpectedly high potency againstor, and for the treatment of other microbial infections.

Nitroimidazooxazine and nitroimidazooxazole analogues and their uses

The invention relates to novel tricyclic 1,2,4-triazine-1-oxides and novel tricyclic 1,2,4-triazine-1,4-dioxides of formula I and to related analogues, to their preparation, and to their use as hypoxia-selective drugs and radiosensitizers for cancer therapy, both alone or in combination with radiation and/or other anticancer drugs.

Tricyclic 1,2,4-triazine oxides and compositions for therapeutic use in cancer treatments

The current invention provides a series of bicyclic nitroimidazole-substituted phenyl oxazolidinones in which a bicyclic nitroimidazole pharmacophore is covalently bonded to a phenyl oxazolidinone, their pharmaceutical compositions, and the method of use of the compositions for prevention and treatment of bacterial infections. The bicyclic nitroimidazole-substituted phenyl oxazolidinones possess surprising antibacterial activity against wild-type and resistant strains of pathogens, and are therefore useful for the prevention, control and treatment of a number of human and veterinary bacterial infections caused by these pathogens, such as

Bicyclic nitroimidazole-substituted phenyl oxazolidinones

Growing community of inventors

Waitakere City, New Zealand

Adrian Blaser