The Procter Gamble Company

Eli Lilly and Company

Edwards Lifesciences Corporation

Adrian Benton James

Robert Allen Godfroid

William Michael Cannon

Richard Michael Harper

Anthony Piazza

Jerome Joo Ge Goh

Samuel Bladgen Truslow

Jonathan Joseph Powell

Bryan Thomas White

Kenton Ray Lynde

Stephanie Lynn Lause

Robert Ian Lister

Jan Hendrik Verbiest

John Philip Stoddard

Jennifer Ellen Davis-Wilson

Leo Kopelow

Jan Hendrik Maria Verbiest

Christine Marie Kurjan

Paulus Antonius Hofte

Diana Nguyen-Thien-Nhon

Brian J Mason

Robert Stobie

Ralph Kafesjian

Andrzej Skoskiewicz

Aaron Ernesto Sklar

Banny Banerjee

Nicola John Policicchio

Michael Jurgen Strasser

Jesse Arnold Fourt

John W Lai

Neil John Rogers

Paul Joseph Silberschatz

Steven Bishop

Paulus Antonius Augustinus Höfte

Virginia Pankratz

Samuel Blagden Truslow

Christine Wei Hsien McElhaney

Jan Hendrick Maria Verbiest

Jerome Jooge Goh

Michael Joseph Shawver

Nancy J Serpiello

David Edwards Mallard

John Wai-Chung Lai

Christine Wei Hsien Mcelhaney

An improved holder and method for implanting a tissue-type prosthetic mitral heart valve that prevents suture looping and ma y also constrict the commissure posts of the valve. An upstanding or shaft member axially positioned on the holder causes the lengths of attachment sutures to extend axially beyond the commissure post tips to create a tent and prevent looping of any of an array of pre-implanted sutures around the tips during deployment of the valve. The shaft member may be axially movable such that it can be initially retracted and then actuated just prior to valve deployment. The shaft member may have notches on its distal tip for capturing the attachment sutures, which are crossed over along the valve axis to ensure engagement by the notches. The attachment sutures may be strands or filaments, or may be wider bands of flexible biocompatible material. If bands are used, they desirably cover the commissure post tips to further help prevent suture looping thereover. The flexible lengths of material extend directly between commissures of the valve, or may extending radially inward from each commissure to a central upstanding member.

Heart valve holder and method for resisting suture looping

An improved holder and method for implanting a tissue-type prosthetic mitral heart valve that prevents suture looping and may also constrict the commissure posts of the valve. An upstanding or shaft member axially positioned on the holder causes the lengths of attachment sutures to extend axially beyond the commissure post tips to create a tent and prevent looping of any of an array of pre-implanted sutures around the tips during deployment of the valve. The shaft member may be axially movable such that it can be initially retracted and then actuated just prior to valve deployment. The shaft member may have notches on its distal tip for capturing the attachment sutures, which are crossed over along the valve axis to ensure engagement by the notches. The attachment sutures may be strands or filaments, or may be wider bands of flexible biocompatible material. If bands are used, they desirably cover the commissure post tips to further help prevent suture looping thereover. The flexible lengths of material extend directly between commissures of the valve, or may extending radially inward from each commissure to a central upstanding member.

Automatic injection device

A pharmaceutical delivery apparatus with an automatic syringe retraction following a manually controlled injection. The apparatus includes a housing (), a syringe carriage (), a medication-filled syringe () held within the carriage, the syringe needle tip being disposed within the housing in a first position and projecting from the housing beyond the housing proximal end for insertion into an injection site in a second position, a manually shiftable plunger (), means on the carriage and the housing and the plunger for causing the carriage to advance from the first position to the second position and for injecting medicine from the syringe when the plunger is manually plunged proximally toward the housing, and means on the carriage and the plunger for causing the carriage to retract from the second position to a position at which the needle tip is disposed within the housing when the plunger shifts distally.

Apparatus for injecting a pharmaceutical with automatic syringe retraction following injection

A delay mechanism for staging the operation of an automatic injection apparatus () to ensure medication contents are properly delivered prior to the needled syringe () of the apparatus being retracted. In one form, the delay mechanism includes a shuttle (), a follower (), a locking member, a damping compound, and a driver and a driver biasing element (). The shuttle is for a needled syringe of the apparatus and includes a first latching element. The follower includes a second latching element and a cammable surface, which second latching element is for cooperating with the first latching element to limit motion of the shuttle relative to the follower in a second direction opposite the first direction. The locking member is movable from a locking position to a release position by engagement with the syringe plunger during an injection, the locking member, when in the locking position, preventing rotation of the follower relative to the shuttle, the locking member, when in the release position, allowing rotation of the follower relative to the shuttle. The damping compound is between the follower and a supporting surface to dampen rotation of the follower relative to the shuttle. The driver is rotatably fixed relative to the shuttle and includes a camming surface. The shuttle allowing retracting of the syringe needle into the housing of the automatic injection apparatus after injection.

Delay mechanism for automatic injection device

A pharmaceutical delivery device with triggered automatic needle insertion and manually controlled pharmaceutical injection. The pharmaceutical delivery device includes a housing, a pharmaceutical containing needled syringe having an injection tip that is recessed within the housing when the syringe is in a first position and which projects from the housing when the syringe is in a second position, a syringe advancing assembly operable to automatically advance the needled syringe from the first position to the second position, a plunger including an input portion projecting from the housing for manual access by a user, wherein the plunger is operable by the user directly shifting the input portion when the syringe is disposed in the second position to inject pharmaceutical from the syringe through the needle at a rate adjustably controlled by a user during the injection, and wherein the plunger includes a plunger extender automatically movable within the housing from a first location to a second location upon the needled syringe advancing from the first position to the second position, wherein the plunger extender, when in the second location, occupies a space vacated by the needled syringe during advancement from the first position to the second position, whereby the plunger input portion remains stationary relative to the housing during the advancement of the needled syringe.

Needled pharmaceutical delivery device with triggered automatic needle insertion and manually controlled pharmaceutical injection

A cleaning implement for removing particulate soils from a compressible resilient surface is provided. The cleaning implement includes a ramp for pressing particulates against the compressible resilient surface and a collection member for collecting the particulates which are projected away from the compressible resilient surface when the cleaning implement is moved across the compressible resilient surface.

Cleaning implements and substrates for cleaning a compressible resilient surface

A cleaning implement is provided for cleaning surfaces with a cleaning substrate. The cleaning implement includes a handle connected via a universal joint to a mop head. A portion of the universal joint forms a handgrip which allows a user to hold the mop head independently from the handle. The cleaning implement has a quick-disconnect mechanism which includes a male element located at a distal end of the handle and a female element located on the universal joint and which allow a user to easily disconnect the handle from the mop head.

Multi-purpose cleaning implement

Disposable non-woven cleaning wipe

Hand grip with ring

Cleaning implement

Growing community of inventors

Palo Alto, CA, United States of America

Adrian Benton James