Avantium International B.v.

Teva Sante

Adriaan Jan Van Langevelde

Gérard Coquerel

Olivier Neckebrock

Franck Patrick Mallet

Laurent Courvoisier

Sébastien Rose

Pierre Leproust

Erwin Blomsma

Stéphanie Graf

Gilles Serrure

Danny Dirk Peter Willem Stam

Christine Besselievre

Franck Mallet

The invention relates to a polymorphic form of (&#x2212;)-modafinil that produces a powder X-ray diffraction spectrum comprising intensity peaks corresponding to interplanar spacings of about 8.54, 4.56, and 3.78 &#x212b;, and a process for the preparation thereof.

Process for the preparation of and crystalline forms of optical enantiomers of modafinil

A method for successively performing a powder diffraction analysis of at least two powder samples being contained in sample holding means. Use is made of an apparatus comprising:&#x2014;a source of radiation being adapted to direct a radiation beam to a power sample,&#x2014;a detector for detecting diffraction radiation of a powder sample,&#x2014;a drive means associated with said sample holding means for effecting a movement of an irradiated powder sample during irradiation and detection. The method comprises the steps of irradiating a powder sample and detecting the diffraction radiation of the powder sample, arranging a further powder sample such that said radiation beam is directed to said further powder sample, and irradiating said further powder sample and detecting the diffraction radiation of said further sample. During irradiation and detecting of each sample the drive means effect a movement of the irradiated sample with respect to the radiation beam for the purpose of improving particle statistics. The sample holding means comprise a common multiple samples holder holding said at least two powder samples. Said drive means effect, during irradiation and detection of a sample contained in said common multiple samples holder, a movement of said common multiple samples holder with respect to the radiation beam.

Method for performing power diffraction analysis

An assembly and method for performing parallel chemical experiments, in particular crystallisation experiments. The assembly has a main body having a first and a second face on opposite sides thereof. Multiple bores extend through said main body between said first and second face. Tubular liners are provided having openings at opposite ends thereof, each liner removably fitting in a bore in the main body. First closure means close the openings of the liners at the first face of the main body. Second closure means close the openings of the liners at the second face of the main body. The first and second closure means are fastenable to said main body, so that an experimentation chamber is defined within each liner.

Assembly and method for performing parallel chemical experiments, in particular crystallisation experiments

The present invention relates to a method for performing a transmission diffraction analysis of an analyte on a support surface, wherein the method comprises: irradiating said analyte with a radiation beam generated by a source of radiation, and detecting said radiation after passing through the analyte. The method is characterised in that irradiation is performed such that the radiation beam strikes the analyte in a substantially vertical and substantially perpendicular direction. Further the present invention relates to an apparatus for performing a transmission diffraction analysis.

Vertical transmission diffraction analysis

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Almere, Netherlands

Adriaan Jan Van Langevelde