American Cyanamid Company

Adolph E Sloboda

Andrew S Tomcufcik

John W Hanifin, Jr

Suresh S Kerwar

John F Poletto

Ralph G Child

Dennis W Powell

Susan C Ridge

Leslie H Sutherland

Edward Laurie Tolman

Substituted 4-quinoline-carboxylic acids useful in the treatment of arthritis and inhibition of progressive joint deterioration are disclosed together with methods of use and synthesis thereof.

2-Phenyl-4-quinoline carboxylic acids

Joint destruction associated with arthritic disease in warm blooded animals is treated with unexpected safety using 3,5-dichloromethotrexate. The therapeutic index therefor is unexpectedly enhanced through combination therapy using a post administration of leucovorin.

Treatment of arthritis with 3,5-dichloromethotrexate

A method of treating neuroimmunologic diseases such as multiple sclerosis and acute disseminated encephalomyelitis using 1,4-dihydroxy-5,8-bis[[(2-hydroxyethylamino)ethyl]amino]anthraquinone, or a pharmacologically acceptable acid addition salt thereof.

Method of treating multiple sclerosis

This disclosure describes compositions of matter useful as anti-inflammatory agents and as inhibitors of the progressive joint deterioration characteristic of arthritic disease and the methods of meliorating inflammation and of inhibiting joint deterioration in mammals therewith, the active ingredients of said compositions of matter being certain 2,4,6-tris(substituted-amino)-s-triazines.

Method of treating arthritic disease

This disclosure describes compatible additive anti-inflammatory compositions comprising certain novel anti-arthritic agents and the known non-steroidal anti-inflammatory agents.

Combinations of agents which give enhanced anti-inflammatory activity

This disclosure describes compositions of matter useful as anti-inflammatory agents and as inhibitors of the progressive joint deterioration characteristic of arthritic disease and the methods of meliorating inflammation and of inhibiting joint deterioration in mammals therewith, the active ingredients of said compositions of matter being certain 2-(substituted-amino)-4,6-bis(alkylamino)-s-triazines.

This disclosure describes new compounds and compositions of matter useful as anti-inflammatory agents and as inhibitors of the progressive joint deterioration characteristic of arthritic disease and the methods of meliorating inflammation and of inhibiting joint deterioration in mammals therewith, the active ingredients of said compositions of matter being certain 2,4,6-tris(substituted-amino)-s-triazines.

2,4,6-Tris-(substituted-amino)-s-triazines

This disclosure describes new compounds and compositions of matter useful as anti-inflammatory agents and as inhibitors of the progressive joint deterioration characteristic of arthritic disease and the methods of meliorating inflammation and of inhibiting joint deterioration in mammals therewith, the novel active ingredients of said compositions of matter being the pharmacologically acceptable cationic salts of benzoylacetonitrile, o-fluorobenzoylacetonitrile, m-fluorobenzoylacetonitrile, p-fluorobenzoylacetonitrile, or mixtures thereof.

Alkali metal and alkaline earth metal salts of benzoylacetonitriles

This disclosure describes compositions of matter useful as anti-inflammatory agents and as inhibitors of the progressive joint deterioration characteristic of arthritic disease, and the methods of meliorating inflammation and of inhibiting joint deterioration in mammals therewith, the active ingredient of said compositions of matter being .beta.-oxo-2-thiophenepropionitrile or the pharmaceutically acceptable cationic salts thereof.

This disclosure describes compositions of matter useful as anti-inflammatory agents and as inhibitors of the progressive joint deterioration characteristic of arthritic disease, and the methods of meliorating inflammation and of inhibiting joint deterioration in mammals therewith, the active ingredients of said compositions of matter being benzimidoylacetonitrile, meta-fluorobenzimidoylacetonitrile, para-fluorobenzimidoylacetonitrile, or mixtures thereof.

Compositions and method of use to treat arthritic disease with

Compositions of matter and method of use to treat arthritic disease

This disclosure describes compositions of matter useful as anti-inflammatory agents and as inhibitors of the progressive joint deterioration characteristic of arthritic disease, and the method of meliorating inflammation and of inhibiting joint deterioration in mammals therewith, the active ingredients of said compositions of matter being benzoylacetonitrile, o-fluorobenzoylacetonitrile, m-fluorobenzoylacetonitrile, p-fluorobenzoylacetonitrile, or mixtures thereof.

Compositions containing benzoylacetonitrile and method of use to treat

A method for the treatment of ocular inflammation by the topical application of p-biphenylacetic acid in a pharmaceutically acceptable carrier.

Growing community of inventors

New City, NY, United States of America

Adolph E Sloboda