Wyeth

Pharmacopeia Drug Discovery, Inc.

Pharmacopeia Drug Disclovery, Inc.

Adolph C Bohnstedt

Celia Kingsbury

Koc-Kan Ho

Vidyadhar Madhav Paradkar

Michael J Ohlmeyer

John J Baldwin

Nasrin Ansari

David J Diller

Steven G Kultgen

Irina Neagu

Yingchun Lu

Roland Ellwood Dolle

Tao Guo

Shawn David Erickson

Michael H Ohlmeyer

Edward McDonald

Dirk Leysen

Jaap Van Der Louw

Michael H J Ohlmeyer

Robert A Horlick

Haengsoon Park

John Richard Morphy

James Inglese

Jorge Quintero

Paolo Giovanni Martino Conti

Kenneth C Appell

Ming You

Zoran Rankovic

The present invention provides novel purinones and purines useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection. The compounds are of the general formulae I and II shown below, in which Q is selected from the group consisting of CX and nitrogen; and A is chosen from the group consisting of H, (C-C) alkyl, heteroaryl, and aryl: 

6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression

The present invention provides novel purines useful for the prevention and treatment of autoimmune diseases, inflammatory diseases, mast cell mediated disease and transplant rejection. The compounds of the general formula I shown below, in which Q is selected from the group consisting of CX and nitrogen; and A is chosen from the group consisting of alkyl, heterocyclyl, aryl, substituted alkyl, substituted heterocyclyl, substituted aryl, and halogen: 

8-substituted 2-(benzimidazolyl)purine derivatives for immunosuppression

The present invention provides novel purine and imidazopyridine derivatives useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection. The compounds are of the general formulas: 

Purine and imidazopyridine derivatives for immunosuppression

A chemical genus of 2-(aminomethyl)arylamides, which are useful as analgesics, is disclosed. The genus is represented by the formula I: A representative example is: 

2-(aminomethyl) arylamide analgesics

Compounds containing the pyrimidine nucleus and their use to treat diseases and conditions related to inappropriate Interleukin-8 receptor activity are disclosed. The compounds are of the formula IIn these compounds, Q is preferably unsubstituted and substituted heterocyclyl; U is usually hydrogen or fluorine; and V is preferably hydrogen, halogen, alkyl, &#x2014;O&#x2014;alkyl or &#x2014;S-alkyl. A representative example is:

Pyrimidine derivatives as IL-8 receptor antagonists

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Burlington, NJ, United States of America

Adolph C Bohnstedt