Cassella Farbwerke Mainkur Aktiengesellschaft

Adolf Stachel, Deceased

Rolf-Eberhard Nitz

Rudi Beyerle

Josef Scholtholt

Otto Grawinger

Eckhard Schraven

Klaus Resag

Heinz Bender

By Ingeburg Stachel, Heiress

Ingeburg Lydia Stachel, Heiress

The present invention relates to new pharmacologically valuable, basically substituted heterocyclic compounds of the formula ##EQU1## wherein X represents

Basically substituted heterocyclic compounds

The present invention relates to new coumarin compounds useful as coronary dilators and having the formula ##SPC1## Or the hydrochloric acid addition salts thereof, and to methods of preparing same either by acylating, in the presence of acid-binding agents, if desired, coumarin derivatives having the formula ##SPC2## With acylating agents selected from the group consisting of alkoxybenzoic acid having the formula ##SPC3## And functional derivatives thereof, or by condensing, in the presence of acid-binding agents, if desired, coumarin derivatives having the formula ##SPC4## With an amine having the formula RH, wherein R is piperazino which is free of acyloxy groups and is bound via a nitrogen atom; R.sub.1 is selected from the group consisting of alkyl radicals having 1-4 carbon atoms and phenyl; R.sub.2 is selected from the group consisting of 5,7-, 6,7- and 7,8-positioned alkoxy groups having 1-4 carbon atoms; R.sub.3 is selected from alkoxy groups having 1-4 carbon atoms; R.sub.4 is selected from the group consisting of chlorine and bromine; R' is piperazino which is free of hydroxy groups and is bound via a nitrogen group; and m is selected from the group consisting of 1, 2, and 3.

Piperazino substituted coumarin derivatives

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Munich, Georgia

Adolf Stachel, Deceased