Biomatrix, Inc.

Union Carbide Corporation

Union Carbide Chemicals and Plastics Company, Inc.

Union Carbide Chemicals & Plastics

Adolf Leshchiner

Endre A Balazs

Philip A Band

Emmett Malone Partain, Iii

Errol D Goddard

Nancy E Larsen

Joseph P Pavlichko

Arminda G Barbone

George L Brode

Pak S Leung

Adelya Leshchiner

Sadek K Hilal

Disclosed are water based, viscoelastic compositions comprising a mixture of high molecular weights hyaluronic acid salts and water soluble poly(ethylene oxides). Also disclosed are cosmetic formulations including said compositions.

Hyakyribate-poly (ethylene oxide) mixtures

Binary polymer mixtures of albumin and glycosaminoglycan and ternary polymer mixtures of polyionic polypeptide and high molecular weight and highly charged polyanions are useful for managing skin including wrinkles or other irregularities. Aqueous compositions of the ternary mixtures have pH dependent phase change properties and provide skin activated films.

Polymer mixtures useful in skin care

Disclosed are drug delivery systems based on a polymeric component which is soluble or insoluble (cross-linked) hyaluronan or hyaluronan copolymerized with another hydrophilic polymer or hylan and one or more substances having biological or pharmacological activity and methods of preparing same.

Drug delivery systems based on hyaluronans derivatives thereof and their

Disclosed is hylan, a chemically modified hyaluronan preparation characterized by the presence of small amounts (0.0002-0.05% by weight) of aldehyde cross-linking groups covalently bonded to the hyaluronan molecular chains. Also disclosed is an improved method of obtaining hylan comprising treating hyaluronan in situ in animal tissues containing same with a treatment mixture including an aldehyde which is reactive towards hyaluronic acid and the proteins contained in the animal tissue. Treatment is effected at temperatures below about 16.degree. C. at very high pH, e.g., 8-14 whereby the overall yield is increased while maintaining the high molecular weight of the hylan.

Hylan preparation and method of recovery thereof from animal tissues

Combinations of glycosaminoglycan and certain cationic polymers provide modified glycosaminoglycan properties and can provide substantivity to keratinous material, compatibility, stability, humectancy, rheology and other properties useful in personal care or medical applications.

Processes for managing keratinous material using glycosaminoglycan and

Percutaneous emboli are formed for therapeutic and/or corrective reasons by using a composition which includes crosslinked gells of hyaluronic acid (HA), hylan (HY) or mixed crosslinked gels of HA or HY with other materials, thrombin and cationic substances containing quaternary ammonium groups. Other optional materials include fillers and radio-opaque substances.

Compositions for therapeutic percutaneous embolization and the use

Glycosaminoglycan and cationic polymer combinations

Disclosed is hylan, a chemically modified hyaluronic acid preparation characterized by the presence of small amounts (0.005-0.05% by weight) of aldehyde cross-linking groups covalently bonded to the hyaluronic acid molecular chains. Also disclosed is a method of obtaining hylan comprising treating hyaluronic acid in situ in animal tissues containing same with a treatment mixture including a reagent (typically an aldehyde) which is reactive towards hyaluronic acid and the proteins contained in the animal tissue.

Chemically modified hyaluronic acid preparation and method of recovery

Disclosed are cross-linked gels of hyaluronic acid, alone or mixed with other hydrophilic polymers and containing various substances or covalently bonded low molecular weight substances and processes for preparing them. These products are useful in numerous applications including cosmetic formulations and as drug delivery systems.

Cross-linked gels of hyaluronic acid and products containing such gels

Disclosed are water based, viscoelastic compositions comprising a mixture of high molecular weights hyaluronic salts and water soluble poly(ethylene oxides). Also disclosed are cosmetic formulations including said compositions.

Hyaluronate-poly (ethylene oxide) compositions and cosmetic formulations

Polymeric materials (and articles made therefrom) including polyurethanes, polyesters, polyolefins, polyamides, polysiloxanes, vinylic and acrylic polymers are rendered biocompatible by including with the polymeric material hyaluronic acid or a salt thereof. The hyaluronic acid may be coated onto the surface of the polymeric material, dispersed throughout the body of the polymeric material, or both. The hyaluronic acid on the surface of the polymeric material may optionally be cross-linked. The biocompatible polymeric materials are used in the making of various prosthetic devices including heart valves, intraocular lenses, vascular grafts, pacemaker leads and the like.

Growing community of inventors

Fairview, NJ, United States of America

Adolf Leshchiner