American Cyanamid Company

Adma S Ross

William V Curran

Andrew S Tomcufcik

James H Boothe

James H Booth

Adamantane 1 carbonyloxymethyl 7.beta.-[2-(2-aminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido]-3-[(1,2,3-th iadiazol-5 yl)-thiomethyl]ceph-3-em-4 carboxylate is disclosed. It and other esters are used as orally administered anti bacterials'.

Esters of cephalosporin derivitives

7-acetamidocephalosporins are disclosed herein which are substituted at position 3 of the cephalosporin nucleus with the group ##STR1## wherein R.sub.2 is selected from the group hydrogen, amino, C.sub.1 to C.sub.6 alkylamino and di-C.sub.1 to C.sub.6 alkylamino and R.sub.3, R.sub.4 and R.sub.5 are the same or different and are selected from the group hydrogen, hydroxy, C.sub.1 to C.sub.6 alkyl, C.sub.1 to C.sub.6 alkoxy, trifluoromethyl, phenyl, substituted phenyl, heterocyclic aryl, and R.sub.3 and R.sub.4 or R.sub.4 and R.sub.5 taken together are the moiety --CH.sub.2 (CH.sub.2).sub.2 CH.sub.2 --.

Cephalosporanic acid derivatives

7-Beta-[alpha-syn-methoxyimino-alpha-(2-aminothiazol-4-yl)acetamido]-3-[(1, 2,3-thiadiazol-5-ylthio)methyl]-3-cephem-4-carboxylic acid and C.sub.1 -C.sub.6 alkyl derivatives thereof, useful as antibacterial agents.

7-Beta-[alpha-syn-methoxyimino-alpha-(2-aminothiazol-4-yl)-aceta

7-acetamidocephalosporins are disclosed herein which are substituted at position 3 of the cephalosporin nucleus with the group ##STR1## wherein R.sub.2 is selected from the group hydrogen, amino, C.sub.1 to C.sub.6 alkylamino and di-C.sub.1 to C.sub.6 alkylamino and R.sub.3, R.sub.4 and R.sub.5 are the same or different and are selected from the group hydrogen, hydroxy, C.sub.1 to C.sub.6 alkyl, C.sub.1 to C.sub.6 alkoxy, trifluoromethyl, substituted phenyl heterocyclic aryl and R.sub.3 and R.sub.4 or R.sub.4 and R.sub.5 taken together are the moiety --CH.sub.2 (CH.sub.2).sub.2 CH.sub.2 --.

This disclosure describes compounds of the class of 6-[D-.alpha.-(substituted-chromone-3-carboxamido)phenylacetamido]-penicill anic acids which possess antimicrobial activity.

3-Chromonecarboxamido derivatives of penicillins

This disclosure describes compounds of the class of 1-(para-substituted-phenyl)-1H-tetrazoles useful as antimicrobial agents.

1-(Para-substituted-phenyl)-1H-tetrazoles

This disclosure describes compounds of the class of 1-(para-substituted-phenyl)-1H-tetrazoles which possess anti-microbial and anti-neoplastic activity.

This disclosure describes compounds of the class of N-substituted p-(1H-tetrazol-1-yl)phenylthio- or dithio-carbamates useful as antimicrobial agents.

Growing community of inventors

Suffern, NY, United States of America

Adma S Ross