American Cyanamid Company

Wyeth Holdings Corporation

Adma A Ross

Joseph J Hlavka

Phaik-Eng Sum

Yakov Gluzman

Ving J Lee

The invention is drawn to 7-substituted-9-(substituted amino)-6-demethyl-6-deoxytetracycline compounds of the formulawherein R, X, Rand Rare defined in the specification. The compounds of the invention are useful as broad spectrum antibiotics.

7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines

The disclosure is drawn to a method of using novel 7-substituted-9-(substituted amino)-6-demethyl-6-deoxytetracycline compounds to treat infections caused by a wide spectrum of bacterial organisms, including those which are resistant to tetracycline.

Method for treating bacterial infection with novel 7-substituted-9-substituted amino 6-demethyl-6-deoxytetracyclines

The disclosure is drawn to novel 7-substituted-9-(substituted amino)-6-demethyl-6-deoxytetracycline compounds. These compounds are useful to treat infections caused by a wide spectrum of bacterial organisms, including those which are resistant to tetracycline.

7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines

Method for treating bacterial infection with novel

The invention is drawn to 7-substituted-9-(substituted amino)-6-demethyl-6-deoxytetracycline compounds of the formula ##STR1## wherein R, X, R.sup.5 and R.sup.6 are defined in the specification. The compounds of the invention are useful as broad spectrum antibiotics.

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Airmont, NY, United States of America

Adma A Ross