Council of Scientific and Industrial Research

Adla Malla Reddy

Ahmed Kamal

Kamal Ahmed

Rajesh V C R N C Shetti

Suresh Paidakula

Bandari Rajendra Prasad

Ashwini Kumar Banala

Yellamelli Valli Venkata Srikanth

Mohammed Ashraf

Rajesh Vcrnc Shetti

K Srinivasa Reddy

Shaikh Faazil Bagwan

Syed Mohammed Ali Hussaini

Neigapula Sankara Rao

Srinivasa K Reddy

Papagiri Venkat Reddy

Ponnampally Swapna

The present invention provides a compound of general formulae A useful as potential anti-cancer agents against human cancer cell lines and a process for the preparation thereof. Where in R, R, R&#x2550;H, alkyl, alkoxy, halo, haloalkyl, halomethoxy, nitro and G= Where in R, R, R&#x2550;H, alkyl, alkoxy, halo, haloalkyl, halomethoxy, nitro and G= 

Amidobenzothiazoles and process for the preparation thereof

The present invention provides a compound of general formulae A useful as potential antitumor agents against human cancer cell lines and a process for the preparation thereof. 

2-anilinonicotinyl based chalcones useful as potential anticancer agents and process for preparation thereof

The present invention provides a compound of general formulae A useful as potential antitumour agents against human cancer cell lines. The present invention further provides a process for the preparation of pyrrolo[2, 1-c][1,4]benzodiazepine hybrids of general formulae 6a-g, 10a-o, 14a-g and 18a-o. 

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The present invention provides compounds of general formula (3) as useful potential antitumour agents against human cancer cell lines. The present invention further provides a process for the synthesis of 4&#x3b2;-acrylamidopodophyllotoxin congeners of general formula (3), wherein R and R1 are an aryl group and R is selected from 3,4,5-trimethoxyphenyl or 2-methoxy phenyl and R1 is selected from the group consisting of 4-hydroxy-3-methoxyphenyl, 3-hydroxy-4-methoxyphenyl, 4-fluoro-3-methoxyphenyl, 3-fluoro-4-methoxyphenyl, 2-fluoro-5-methoxyphenyl, 2-fluoro-4-methoxyphenyl, 4-hydroxy-3-nitrophenyl, 4-methoxy-3-nitrophenyl, 4-nitrophenyl, 3-nitrophenyl, 2-nitro phenyl, 4-methoxyphenyl, 3-methoxyphenyl and 4-hydroxyphenyl. 

Substituted 4-&#x3b2;-acrylamidopodophyllotoxin congeners as antitumour antibiotics and the process for preparation thereof

A compound of general formula 9, useful as potential antitumor agents against human cancer cell line and a process for the preparation of Pyrrolo[2,1-c] [1,4]benzodiazepine-benzothiazole or benzoxazole conjugates linked through piperazine of general formula 9 wherein: R, R=H, F, OCF, Cl, OMe; R=OCH3 or H; nn=3, 4; x=S or O.

Pyrrolo[2,L-C][L,4]benzodiazepine-benzothiazole or benzoxazole conjugates linked through piperazine moiety and process for the preparation thereof

The present invention relates to chalcone linked pyrrolo[2,1-c][1,4]benzodiazepine hybrids and a process for the preparation there of. More particularly it relates to 7-Methoxy-8-{n[4-1-(2 or 4-substituted phenyl)-3-(4-hydroxy-3-methoxyphenyl)-2-propen-1-one]alkyl}-oxy}-(11aS)-1,2,3,11a-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one and 7-Methoxy-8-{n-[-3-(4-hydroxy-3-methoxyphenyl)-1-(2,4-alkyl-3-quinolyl)-2-propen-1-one]alkyl}-oxy-(11aS)-1,2,3,11a-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one with aliphatic chain length variations useful as anticancer (antitumor) agent. The general structural formula of these chalcone linked pyrrolo[2,1-c][1,4]benzodiazepines hybrids is given below. wherein R=OH, methyl, ethyl or phenyl; R=H, OH or F; R=H or methyl; x=c or N; n=1-4. 

The present invention provides a compound of general formula 5, useful as potential antitumour agents against human cancer cell lines. The present invention further provides a process for the preparation of pyrrolo[2,1-c][1,4]benzodiazepine hybrids of general formula (5): wherein n=3, 4, 5, 6, 8 and wherein R1 and Ris selected from the group consisting of R&#x2550;H, R&#x2550;H or R&#x2550;CHO, R2=CHO or R&#x2550;CHO and R&#x2550;CHO. 

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Hyderabad Telangana, India

Adla Malla Reddy