Recurium IP Holdings, LLC

Aditya Krishnan Unni

Kevin Duane Bunker

Peter Qinhua Huang

Sunny Abraham

Brant Clayton Boren

Sunil Paliwal

Joseph Robert Pinchman

Chad Daniel Hopkins

Sayee Gajanan Hegde

Benjamin Pratt

Hui Liu

Sobhana Babu Boga

Disclosed herein are methods for preparing tertiary alcohols from an optionally substituted phenyl ketone or an optionally substituted pyridinyl ketone that includes the use of a chiral ligand and boron trifluoride diethyl etherate. Tertiary alcohols can be used to prepare synthetic versions of natural products and/or pharmaceuticals.

Chiral synthesis of a tertiary alcohol

Processes of making [1.1.1]propellane utilize reaction conditions that include reacting 1,1-dibromo-2,2-bis(chloromethyl)cyclopropane with an effective amount of solid magnesium.

Process for making [1.1.1]propellane

Compounds of Formula (I) are provided herein. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular proliferation, such as breast cancer.

Substituted 1,2-dihydro-3H-pyrazolo[3,4-D]pyrimidin-3-ones

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San Diego, CA, United States of America

Aditya Krishnan Unni