The United States of America, As Represented by the Secretary, Department of Health and Human Services

Wayne State University

Semmelweis University

Genesis Theranostix Korlatolt Felelossegu Tarsasag

Adi L Tarca

Roberto Romero

Sonia S Hassan

Tinnakorn Chaiworapongsa

Piya Chaemsaithong

Hamutal Meiri

Adrienna Katalin Kekesi

Zoltan Papp

Offer Erez

Nandor Than

Gabor Juhasz

Adrienna Katalin KÉKESI

Zoltán Papp

Gábor JUHÁSZ

Nándor Than

Kits and methods to distinguish between false and true labor are provided. The kits and methods can utilize differences in abundance and/or differences in the rate of change in abundance of B7-H2, SORC2, TF, C1-Esterase Inhibitor, Ran, IMDH1 and/or PGAM1, as markers of true labor.

Kits and methods to distinguish false labor and true labor

Biomarkers tests which can be used to predict a positive or negative risk of preeclampsia are described. More specifically, a panel of biomarkers including MMP-7 and gpIIbIIIa, described. The test is useful to predict preeclampsia when a biological sample is obtained between the 16and 22week of pregnancy. Prediction later in pregnancy can be achieved by a combination of Siglec-6, Activin A, ALCAM, and/or FCN2.

Kits and methods for prediction and treatment of preeclampsia

Biomarkers tests which can be used to predict a positive or negative risk of preeclampsia are described. More specifically, a panel of biomarkers including MMP-7 and gpIIbIIIa, described. The test is useful to predict preeclampsia when a biological sample is obtained between the 16th and 22nd week of pregnancy. Prediction later in pregnancy can be achieved by a combination of Siglec-6, Activin A, ALCAM, and/or FCN2.

Kits and methods to distinguish between false and true labor are provided. The kits and methods can utilize differences in abundance and/or differences in the rate of change in abundance of B7-H2, SORC2, TF, C1-Esterase Inhibitor, Ran, IMD-H1 and/or PGAM1, as markers of true labor.

Provided are systems and methods to identify subjects at risk for preterm labor and/or preterm birth. The systems and methods utilize biomarkers. Also provided are systems and methods for decreasing the risk of preterm labor by administering a treatment following a positive risk identification.

Systems and methods to predict risk for preterm labor and/or preterm birth

Disclosed are specific biomarkers that allow for early testing of preeclampsia/HELLP syndrome. Thus, a method is provided predicting preeclampsia in a pregnant woman. Also disclosed is a kit comprising means for assaying a sample from a pregnant woman for the concentrations of the specific biomarkers.

Growing community of inventors

South Lyon, MI, United States of America

Adi L Tarca