Cardiac Pacemakers, Inc.

Boston Scientific Scimed, Inc.

Mayo Foundation for Medical Education and Research

Adeniyi O Aremu

David R Wulfman

Joseph T Delaney, Jr

Adegbola O Adenusi

Gregory J Sherwood

James P Rohl

Mary M Byron

Danielle Frankson

Angelo Fruci

Adam McGraw

Samuel J Asirvatham

Martyn G Folan

David R Holmes, Iii

Joel T Eggert

Timothy A Ostroot

Thomas M Keating

Douglas Dean Pagoria

Matthew Montague

Nicholas Lee Tassoni

Daniel Keith Tomaschko

Damien Vincent Nolan

Martin Hynes

Patrick Willoughby

Sarah Melissa Gruba

Suraj Kapa

Todd College

Douglas Pennington

James A Klos

Niraj Gurung

John D Kroeger

Hoi Ki Ricky Chow

David Pettijohn

Jr Joseph T Delaney

An implantable medical device includes a polymer substrate and at least one nanofiber. The polymer substrate includes a surface portion extending into the polymer substrate from a surface of the substrate. The at least one nanofiber includes a first portion and a second portion. The first portion is interpenetrated with the surface portion of the substrate, and mechanically fixed to the substrate. The second portion projects from the surface of the substrate.

Durable antimicrobial layer for implantable medical devices

A medical device may include a tubular sleeve configured for implantation in a body lumen, the sleeve having a first configuration with a first rigidity and a second configuration with a second rigidity greater than the first rigidity, the sleeve including: a flexible membrane defining an interior lumen; and a channel extending along the membrane.

Deployable sleeves and related methods

A vascular occlusion device for deployment within a lumen of a vessel may include a self-expanding frame configured to shift between a collapsed configuration and an expanded configuration, the self-expanding frame defining a perimeter of an interior space disposed within the self-expanding frame, and an occlusive membrane secured to the self-expanding frame. The occlusive membrane may include a suspended portion disposed within the self-expanding frame and spaced apart from the perimeter of the interior space.

Vascular occlusion device

A method of making a solution including poly(ethylene terephthalate). The method includes dissolving poly(ethylene terephthalate) in a solvent mixture to form a solution, the solvent mixture including two solvent components. A Hansen Solubility Parameter Distance between the solvent mixture and HSP coordinates having a dispersion HSP of 18.02 MPa, a polar HSP of 5.56 MPa, and a hydrogen bonding HSP of 14.27 MPais less than about 2 MPa.

PET solutions and methods of making PET solutions for medical devices

A medical device made of a hybrid polymeric structure includes a tubular body including a first layer and a second layer. The first layer includes a fibrous matrix comprising a plurality of randomly oriented nanofibers made at least in part of a first polymeric material and pores formed between at least a portion of the nanofibers. The second layer is made at least in part of a second polymeric material. At least a portion of the second layer is disposed about and between the plurality of nanofibers such that at least a portion of the second polymeric material is embedded into at least a portion of the pores of the fibrous matrix.

Medical device hybrid polymeric structures and coatings with improved lubricity and durability

Various aspects of the present disclosure are directed toward apparatuses, systems, and methods for applying ablation therapy to a tissue region. The apparatuses, systems, and methods may include a balloon structure and one or more electrodes arranged on or within the balloon structure and configured to deliver energy to the tissue region.

Stenosis prevention and ablation delivery system

An implantable drug eluting medical device includes a polymer substrate having a surface, a first plurality of nanofibers, and at least one antimicrobial drug. Each of the first plurality of nanofibers includes a first portion interpenetrated with the surface of the substrate to mechanically fix the nanofiber to the substrate, and a second portion projecting from the surface. The at least one antimicrobial drug is disposed within or among the second portion of the first plurality of nanofibers.

Infection fighting drug eluting device

A method for making a device including a polyisobutylene-polyurethane block copolymer. The method includes polymerizing a polyisobutylene diol, a diisocyanate, and a chain extender within a solvent system to form a polyisobutylene-polyurethane block copolymer solution, depositing the polyisobutylene-polyurethane block copolymer solution onto at least a portion of the device, and evaporating the solvent system from the deposited polyisobutylene-polyurethane block copolymer solution.

Production of in situ crosslinkable polyisobutylene-polyurethane nanofibers and coatings

A method for making a tubular medical device having a hybrid polymeric structure includes forming a first layer comprising a non-woven fibrous matrix made of a first polymeric material and forming a second layer comprising a second polymeric material about the first layer such that at least a portion of the second polymeric material of the second layer embeds into at least a portion of the first polymeric material of the first layer.

Method for making a tubular medical device

A medical electrical lead includes an insulative lead body extending from a distal region to a proximal region, a conductor disposed within the insulative lead body and extending from the proximal region to the distal region, an electrode disposed on the insulative lead body and in electrical contact with the conductor, and a fibrous matrix disposed on at least part of the electrode. The fibrous matrix includes fibers. The fibers include a polyvinylidene fluoride-based (PVDF-based) polymer and a crystal-modifying additive. The PVDF-based polymer includes an amorphous PVDF phase and a crystalline PVDF phase. The crystalline PVDF phase includes a beta form crystalline structure in an amount exceeding any other crystalline structure form in the crystalline PVDF phase.

Medical electrical lead with biostable PVDF-based materials

Growing community of inventors

Brooklyn Park, MN, United States of America

Adeniyi O Aremu