International Business Machines Corporation

Fundacao Oswaldo Cruz

Universidade Federal De Minas Gerais - Ufmg

Ademir Ferreira Da Silva

Mathias B Steiner

Ricardo Luis Ohta

Jaione Tirapu Azpiroz

Matheus Esteves Ferreira

Daniel Vitor Lopes Marcondes Marçal

Michael Engel

Julio Nogima

Sergio Borger

Marcia Ito

Andre De Oliveira Botelho

Nara Mazarakis Rubim

Pedro Paulo Ferreira Ribeiro

Edimilson Domingos Da Silva

Alecio Pedro Delazari Binotto

Ado Jorio De Vasconcelos

Percival Silva De Lucena

Fabio Latuf Gandour

Antonio Gomez Pinto Ferreira

Antonio Gomes Pinto Ferreira

A multiplexed lateral flow device includes an impermeable internal reservoir having an opening to receive a sample deposition. A fluid distributor pad is arranged in fluid communication with a lower surface of the internal reservoir. The fluid distributor pad includes a paper based microfluidic element having a pattern of a hydrophobic material to distribute a portion of the sample deposition substantially equally among a plurality of flow paths. Lateral flow assays having a plurality of flow lines are aligned with flow paths of the distributor pad. An impermeable top cover has a first window arranged over the opening of the internal reservoir, and at least a second window arranged over the test results of the lateral flow assays. A housing element houses the reservoir, the distributor pad and lateral flow assays. The housing element includes an impermeable bottom cover and a spacer element arranged between the top and bottom covers and, provides a gap between the lateral flow assays and the impermeable top cover.

Multiplexed lateral flow assay device

A validation method applied to sensor data prior to submitting to a blockchain, a computer program product, and a system for validating chemical data. One embodiment may comprise receiving a sensor captured result at an application, applying the sensor captured result to a domain-specific statistical model of expected range of variability of measured results to extract a distribution of expected sensor values, computing a confidence value in the sensor captured result using the domain-specific statistical model, validating the confidence value against a required threshold of confidence, and submitting the sensor captured result for appending to the blockchain if the confidence level is validated against the threshold of confidence.

Validating test results using a blockchain network

A multiplexed testing strip testing device includes a hydrophobic paper-based strip housing element configured for placement of one or more testing strips. One or more alignment markers on the hydrophobic paper-based housing element are marked to facilitate placement of the one or more testing strips. A cover element is arranged above the strip housing element and includes a machine-readable test identifier on an upper surface. A removably attached filtering element is arranged on the hydrophobic paper-based strip housing element.

Multiplexed testing strip device

Devices and methods for controlling collection of liquid sample are described. In an example, a microfluidic device can include an analytical device and an actuator. The actuator can be connected to the analytical device. The actuator can be operable to absorb fluid. The actuator can guide the absorbed fluid to an input layer of the analytical device. The actuator can deform in response to an occurrence of an absorption condition. A degree of deformation of the actuator indicates a volume of fluid collected by the analytical device.

Precise fluid input control for point-of-care devices

A multiplexed lateral flow assay device includes an impermeable internal reservoir having an opening to receive a sample deposition. A fluid distributor pad is arranged in fluid communication with a lower surface of the internal reservoir and divides a portion of the sample deposition substantially equally among a plurality of flow paths. Lateral flow assays having a plurality of flow lines are aligned with flow paths of the distributor pad. An impermeable paper top cover has a first window arranged over the opening of the internal reservoir, and at least a second window arranged over the test results of the lateral flow assays. A housing element houses the reservoir, the distributor pad and lateral flow assays. The housing element includes an impermeable bottom cover and a spacer element arranged between the top and bottom covers and, provides a gap between the lateral flow assays and the impermeable paper top cover.

An embodiment includes a sample receiving region, a first diagnostic element that includes one or more colorimetric analysis regions, and a second diagnostic element that includes one or more lateral flow assay analysis regions. The embodiment also includes a first flow path that allows a portion of a liquid deposited at the sample receiving region to flow to the first diagnostic element. The embodiment also includes a second flow path that allows a portion of the liquid deposited at the sample receiving region to flow to the second diagnostic element.

Rapid test device having multiple heterogeneous diagnostic methods

A rapid test device includes a micropad chip configured for a multi-parameter chemical testing of an input sample. A plurality of paper layers of the micropad chip are in fluid communication, including a sample absorption element, a filtering element configured to filter the input sample, and a sample distribution element configured to distribute the input sample received from the filtering element to a remainder of the plurality of paper layers. One or more reacting elements associated with the multi-parameter chemical testing of the input sample have one or more colorimetric reagents in fluid communication with the sample distribution element. A colorimetric result displaying element in fluid communication with the one or more reacting elements is configured to display a colorimetric result of the testing of the input sample with the at least one reacting element for a respective chemical test of the multi-parameter chemical testing.

Rapid testing device for wastewater analysis

Fabricating a fluid testing device includes receiving a substrate, and applying a pattern of hydrophobic material to the substrate. The substrate is positioned between layers of a thermally reflective material. Heat and pressure is applied to the substrate and thermally reflective material to reflow the pattern of hydrophobic material. A protective coating is applied over a portion of the substrate to form the fluid testing device.

Fabrication of paper-based microfluidic devices

A computer-implemented method, computer program product and prototyping platform creates a design blueprint for a substrate-based microfluidic device. A design and prototyping platform receives at least one blueprint parameter and at least one constraint associated with a proposed substrate-based microfluidic device including a hydrophilic material and arrangement of a pattern of a hydrophobic material. The platform determines an arrangement of a plurality of microfluidic device elements as candidates for implementation of the proposed substrate-based microfluidic device and outputs a design blueprint of the proposed substrate-based microfluidic device.

Platform for design and prototyping of micro paper based devices

A target sample to be chemically analyzed is received at a microfluidic device which is part of an analysis card. The microfluidic device includes at least one input layer configured to receive the target sample, at least one intermediary layer, and at least one readout layer configured to present one or more color attributes at one or more readout regions in response to one or more colorimetric reactions to the target sample. An image of the readout layer of the microfluidic device is obtained. A calibration file that corresponds to the analysis card is obtained. The calibration file includes a calibrated model of at least one color attribute based on data from at least one known chemical attribute of at least one standard sample processed by a calibration card. A data processing function is executed on the obtained image by comparing the one or more color attributes at the one or more readout regions to the calibrated model of the at least one color attribute to determine at least one chemical attribute of the target sample.

Mobile chemical analysis

A method and system for receiving, at a sampling location recommendation module, conventional and complementary information regarding a liquid distribution system, wherein the complementary information includes at least one of a social media post or a consumer report; processing the complementary information and a database of the liquid distribution system in the sampling location recommendation module, using computational and artificial intelligence algorithms, to generate a list of locations for sampling the liquid distribution system; displaying the list of locations; receiving a geo-tagged test record indicative of a sampled contaminant concentration value of at least one location of the list of locations; processing the geo-tagged test record, at a contamination source mapping module, to estimate a location and risk of a contamination source in the liquid distribution system; and displaying the estimated location and risk of the contamination source by modifying a map of the liquid distribution system.

Detecting contamination sources in liquid distribution systems

A growth chamber chip includes a base surrounding a growth chamber; a growth medium within the growth chamber; a sensor package within the growth chamber; a sensor feedthrough extending from the sensor package through a portion of the base to an outer surface of the base; and a transparent seal covering the growth chamber. In one or more embodiments, the base includes a nutrient channel connected in fluid communication with the growth medium and exposed to an outer surface of the base. One or more embodiments provide an array of growth chamber chips, with a movable arm that is movable across the array to individually scan each of the growth chamber chips.

Miniaturized precision agriculture

In response to receiving an input of a user criteria for operating a system, one or more predictive models are selected in dependence on the user criteria. The predictive models predict behavior of the system and are stored in the memory with one or more system performance models that control operation of the system. The selected performance model(s) is implemented to select a subset of sensors that monitor physical conditions of the system and/or environmental parameters thereof, and is also used to select one or more of the system performance models that conform to the user criteria. One or more actuators associated with the system are controlled according to inputs received from the selected subset of sensors and the selected performance model(s). The same concepts are valid for other areas rather than maintenance, like optimization in the area of the internet of things, dynamic system reconfiguration, preventive healthcare.

Dynamic and reconfigurable system management

A system to measure effectiveness of displayed content includes a video processing service configured to receive and process a stream of video images captured by one or more video cameras, a display application service configured to produce display content to be displayed on one or more display monitors and to capture user interactions with the displayed content, and a display effectiveness service configured to correlate data received from the video processing service and the display application service and generate a display effectiveness measurement that is a measure of an effectiveness of the displayed content for specific periods of time.

Growing community of inventors

Sao Paulo, Brazil

Ademir Ferreira Da Silva