The Procter Gamble Company

Warner Chilcott Company, LLC

Isis Innovation Limited

Givaudan S.a.

Adam W Mazur

Frank Hallock Ebetino

Gary A Piazza

George D Hiler

Roy Lee Martin Dobson

Bernard William Kluesener

Magda El-Nokaly

Russell James Sheldon

Mark Walden Lundy

Feng Wang

Robert Graham Russell

Jay Patrick Slack

Stanislaw Pikul

Laura J Crane

Christophe Claude Galopin

Gordon K Stipp

George Douglas Hiler, Ii

Stefan Michael Furrer

Gerald B Kasting

Pablo Victor Krawec

David R Nau

Bruce P Daggy

Lucienne Cole

Robert Graham Goodwin Russell

Novel bisphosphonate cyclic acetal compounds are disclosed, as well as methods of preparing the compounds, pharmaceutical compositions including the compounds, and administration of the compounds in methods of treating bone metabolism disorders, such as abnormal calcium and phosphate metabolism.

Bisphosphonate compounds

Novel imidazo[1,2-&#x3b1;]pyridinyl bisphosphonate compounds are disclosed, as well as methods of preparing the compounds, pharmaceutical compositions including the compounds, and administration of the compounds in methods of treating abnormal calcium and phosphate metabolism, including bone and joint diseases and other disorders.

Imidazo[1,2-a] pyridinyl bisphosphonates

Novel 5-azaindole bisphosphonate compounds are disclosed, as well as methods of preparing the compounds, pharmaceutical compositions including the compounds, and administration of the compounds in methods of treating abnormal calcium and phosphate metabolism, including bone and joint diseases and other disorders.

5-azaindole bisphosphonates

A compound of the formula I in which X and Y are selected as follows:  The compounds have cooling properties and are useful in, for example, foodstuffs, dentifrices and cosmetics.

Menthane carboxamide derivatives having cooling properties

Disclosed are MC-4 and/or MC-3 receptor ligands having the formula:wherein B is a suitable linking group comprising a least one amino acid.

Melanocortin receptor ligands

Disclosed are novel saponins containing 5-C-hydroxymethylhexose and a sterol or triterpene. These materials, when consumed by humans and animals, lower the cholesterol level in the blood. These compounds can be administered as pharmaceutical preparation to the diet, or incorporated into food compositions.

Cholesterol lowering compounds

The subject invention involves a method for treating hyperproliferative conditions in mammalian epithelial cells comprising administering to the mammal a composition containing a safe and effective amount of a lysophosphatidic acid compound or derivative having the structure ##STR1## or a cyclic derivative thereof having the structure ##STR2## or a pharmaceutically acceptable salt thereof, wherein: a) --Y-- is --0-- or --CH.sub.2 --;

Methods of using lysophosphatidic acid for treating hyperproliferative

The subject invention relates to methods for regulating wrinkles in mammalian skin comprising topical application of a lysophosphatidic acid compound having the structure: ##STR1## or a cyclic derivative thereof having the structure: ##STR2## or a pharmaceutically acceptable salt thereof, wherein --R is unsubstituted or substituted, saturated or unsaturated, straight or branched chain alkyl having from 12 to about 23 carbon atoms; each --X-- is independently --O-- or --S--; and --Y-- is --O-- or --CH.sub.2 --.

Methods of using lysophosphatidic acids for regulating skin wrinkles

The subject invention relates to compositions and methods for regulating wrinkles in mammalian skin by topical application of a 2-deoxy- or 2-deoxy-2-halo-lysophosphatidic acid compound having the structure: ##STR1## or a pharmaceutically acceptable salt thereof, wherein --R is unsubstituted or substituted, saturated or unsaturated, straight or branched chain alkyl having from 11 to about 23 carbon atoms; each --X-- is independently --0-- or --S--; --Y-- is --0-- or --CH.sub.2 --; and Z is --H or halo.

Topical composition and method containing deoxy and halo derivatives of

A method of isolating and purifying galactose oxidase from a fungus media is disclosed. The supernatant liquid from the fermentation broth is subjected to ultrafiltration and then separated on a carboxy-sulfon cation exchange column using high performance liquid chromatography. Copper ions must be present to insure enzyme activity.

Process for isolating galactose oxidase

A process for the selective hydrolysis of triglycerides to mixtures of 1,3 or 2,3-diacyl glycerides and 2-acyl glycerides is disclosed. This process uses an alkyl alcohol selected from the group consisting of 2-methyl-2-propanol, 2-butanol and the primary, secondary or tertiary branched or straight chain alkyl alcohols having from 5 to 8 carbon atoms, and mixtures thereof, an aqueous buffer system and a 1,3-lipase. The 2-acyl glycerides in the mixture are esterified to make stereospecific 1,2-diacyl glycerides or 2,3-diacyl glycerides with acid anhydrides and a lipase catalyst. Under the reaction conditions, there is little rearrangement of the diacyl glycerides in the mixture and less than 20% triglyceride is formed. Stereospecific 1,2,4-triglycerides can be made from these materials by standard esterification reactions under conditions which control rearrangement.

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Cincinnati, OH, United States of America

Adam W Mazur