3m Innovative Properties Company

Kindeva Drug Delivery, L.p.

Kindeva Holdco L.p.

Adam S Cantor

Franklyn L Frederickson

Peter R Johnson

Ted K Ringsred

Thu-Van T Tran

Joaquin Delgado

Stephen W Stein

Adam J Stuart

Erik J Johnson

Michael W Mueting

James Patrick DiZio

Chan U Ko

Hye-Ok Choi

David H Brandwein

David J Colburn

Amy Preszler Prince

Andrew J Stockholm

Jerome E Gysbers

Patrick J Young

Jacqueline M Ganser

Terrance W Ocheltree

Cynthia A Robles

Stephen J Woehrle

Michael L Husberg

Sarah Sykora

John R Hart

A dispensing assembly for a container filled with a medicinal substance or formulation, the container being suitable for administering the medicinal substance or formulation via inhalation, buccal or sublingual delivery. The dispensing assembly includes a housing () defining a patient port through which, in use, the medicinal substance or formulation is dispensed. The dispensing assembly further includes a cap () that can be engaged with and disengaged from the patient port to close and open the patient port and an adhesive tape () having one portion () affixed to the housing and a second portion () affixed to the cap, such that when the cap is disengaged from the patient port, the cap is still connected to the housing.

Dispensing assembly

The present disclosure provides a low-profile system and methods for delivering a microneedle array. The delivery system includes a housing that may be secured to and temporarily worn on a patient's skin. A carrier assembly coupled to a microneedle array is received in the housing proximate an applicator device. The carrier assembly is at least releasably secured to the housing and it is typically not attached or otherwise fixed to any portion of the applicator device.

Integrated microneedle array delivery system

A method of making a dry powder pharmaceutical composition comprising: providing inactive ingredient particles; providing a micronized active ingredient; mixing the inactive ingredient particles with surface-modified nanoparticles to provide an inactive ingredient comprised of particles having surfaces with the surface-modified nanoparticles deposited on the surfaces; and/or mixing the micronized active ingredient with surface-modified nanoparticles to provide a micronized active ingredient comprised of particles having surfaces with the surface-modified nanoparticles deposited on the surfaces; and then mixing the micronized active ingredient with the inactive ingredient; the dry powder compositions made by the method; a use of said composition for the manufacture of a medicament for being delivered to the lungs of a mammal by administering a therapeutic amount of the dry powder pharmaceutical composition, and a dry powder inhalation device comprising a mouth piece, a powder containment system, and the dry powder pharmaceutical composition are disclosed.

Dry powder pharmaceutical compositions for pulmonary administration, and methods of manufacturing thereof

A transdermal adhesive patch assembly and method of using same. The assembly can include a backing, and an adhesive and a matrix coupled to the backing. The matrix can include an active ingredient. The assembly can further include a microneedle array in at least partially overlapping relationship with the matrix; and a carrier that couples the microneedle array to the matrix opposite the backing, wherein the carrier and the microneedle array form a skin treatment assembly that, along with the matrix, can be located on a flap. The method can include adhering at least a portion of the adhesive to skin to form an anchor; applying pressure adjacent the microneedle array to treat an area of the skin; moving the flap away from the skin; removing the skin treatment assembly to expose the matrix; and replacing the flap to position the matrix over the treated area of the skin.

Transdermal adhesive patch assembly with removable microneedle array and method of using same

An applicator used to apply microneedle arrays to a mammal. In particular, an application device for applying a microneedle device to a skin surface comprising a flexible sheet having a raised central area attached to the microneedle device and a supporting member at or near the periphery of the flexible sheet, wherein the flexible sheet is configured such that it will undergo a stepwise motion in the direction orthogonal to the major plane of the sheet.

Low-profile microneedle array applicator

An applicator () used to apply microneedle arrays () to a mammal. In particular, an application device for applying a microneedle device () to a skin surface comprising a flexible sheet () having a raised central area () attached to the microneedle device and a supporting member at or near the periphery of the flexible sheet, wherein the flexible sheet is configured such that it will undergo a stepwise motion in the direction orthogonal to the major plane of the sheet.

Transdermal drug delivery compositions comprising pressure sensitive adhesive microspheres that contain a softening agent and/or a drug. Typically the microspheres contain at least 10 wt-% of a softening agent. The drug and/or softening agent can be incorporated into the microspheres during or after their formation.

Adhesive microsphere drug delivery composition

Growing community of inventors

River Falls, WI, United States of America

Adam S Cantor