Corning Incorporated

Adam Robert Sarafian

Robert Anthony Schaut

Steven Edward DeMartino

John Stephen Peanasky

Patrick Joseph Cimo

Connor Thomas O'Malley

Timothy Michael Gross

Jian Luo

Sinue Gomez-Mower

James Ernest Webb

Joseph Michael Matusick

Lina Ma

Douglas Miles Noni, Jr

Kevin Patrick McNelis

Amber Leigh Tremper

Christy Lynn Chapman

Shivani Rao Polasani

Weirong Jiang

Christie Leigh McCarthy

Jared Seaman Aaldenberg

Bryan James Musk

Eric Lewis Allington

Kristen Dae Waight

Michael Clement Ruotolo, Jr

Dane Alphanso Christie

Jingshi Wu

Zheming Zheng

Jiangtao Wu

Alicia Marie Gallagher

Michael Clement Ruotolo

Alexander I Priven

Antoine Marie Joseph Lepicard

A sealed pharmaceutical container comprises a shoulder, a neck extending from the shoulder, and a flange extending from the neck. The flange comprises an outer surface extending from the underside surface and a contact surface extending between the outer surface and an inner surface defining an opening in the sealed pharmaceutical container. The contact surface comprises an outer peripheral edge disposed proximate to the outer surface of the flange. The sealed pharmaceutical container comprises a sealing assembly comprising a stopper extending over the contact surface of the flange and covering the opening, and a cap securing the stopper to the flange. The stopper comprises a sealing surface that is secured in contact with the contact surface of the flange to form a seal between the flange and the stopper. An outer peripheral edge of the sealing surface is disposed at or radially inward of the outer peripheral edge.

Container closure system and sealing assemblies for maintaining seal integrity at low storage temperatures

A glass cartridge comprises a cylindrical body portion comprising an outer diameter Dand an average sidewall thickness T, the cylindrical body portion having a first end and a second end opposite the first end; an opening at the first end of the cylindrical body portion; a shoulder extending radially inward from the second end of the cylindrical body portion; and a neck extending from the shoulder and comprising an outer neck diameter Nthat is less than the outer diameter Dof the cylindrical body portion. The average wall thickness Tis less than or equal to 0.85*s, wherein sis a wall thickness of a standard glass cartridge defined by ISO 13926-1:2004 having an outer diameter dthat is closer to the outer diameter Dthan the outer diameter dof any other standard glass cartridge defined by ISO 13926-1:2004.

Glass containers for storing pharmaceutical compositions

A glass container includes a glass body comprising an external surface, an internal surface opposite the external surface, a thickness T extending between the external surface and the internal surface, and an external surface layer extending from the external surface into the thickness of the glass body, wherein the external surface layer has a porosity greater than a porosity of a remainder of the glass body extending from the external surface layer to the internal surface.

Porous glass containers and methods for making the same

Glass-based articles that include a reduced Young's modulus layer extending from a surface of the glass-based article to a depth of layer and an optional compressive stress layer extending from a surface of the glass-based article to a depth of compression are formed by exposing glass-based substrates to water vapor containing environments. The methods of forming the glass-based articles may include elevated pressures and/or multiple exposures to water vapor containing environments. The glass-based articles may be utilized in foldable or flexible electronic devices.

Glasses with modified young's modulus profile

Disclosed herein are glass pharmaceutical vials having sidewalls of reduced thickness. In embodiments, the glass pharmaceutical vial may include a glass body comprising a sidewall enclosing an interior volume. An outer diameter D of the glass body is equal to a diameter di of a glass vial of size X as defined by ISO 8362-1, wherein X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1. However, the sidewall of the glass pharmaceutical vial comprises an average wall thickness Tthat is less than or equal to 0.85*s, wherein sis a wall thickness of the glass vial of size X as defined by ISO 8362-1 and X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1.

Glass-based articles that include a compressive stress layer extending from a surface of the glass-based article to a depth of compression are formed by exposing glass-based substrates to water vapor containing environments. The methods of forming the glass-based articles may include elevated pressures and/or multiple exposures to water vapor containing environments.

Glass compositions and methods for strengthening via steam treatment

Disclosed herein are glass pharmaceutical vials having sidewalls of reduced thickness. In embodiments, the glass pharmaceutical vial may include a glass body comprising a sidewall enclosing an interior volume. An outer diameter D of the glass body is equal to a diameter dof a glass vial of size X as defined by ISO 8362-1, wherein X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1. However, the sidewall of the glass pharmaceutical vial comprises an average wall thickness Tthat is less than or equal to 0.85*s, wherein sis a wall thickness of the glass vial of size X as defined by ISO 8362-1 and X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1.

Caps for sealing assemblies for sealing glass containers and maintaining container closure integrity at −80° C. or less are disclosed. The caps include a cap skirt having an annular body and a crimp region. The crimp region is a crimpable metal. The annular body of the cap skirt has a coefficient of thermal expansion (CTE) greater than a CTE of a metal consisting of aluminum, a stiffness greater than or equal to 2 times a stiffness of the crimp region, or both. The greater CTE, stiffness, or both of the cap skirt increase the seal pressure and contact area between the stopper and glass container when cooled to −80° C. or less. The caps enable the sealing assemblies to maintain a helium leakage rate of the sealed glass container of less than or equal to 1.4×10cm/s at −80° C. or less.

Cap design for pharmaceutical container closure systems

A sealed pharmaceutical container includes a shoulder, a neck extending from the shoulder, and a flange extending from the neck. The flange includes an inclined sealing surface defining an opening in the sealed pharmaceutical container. The sealed pharmaceutical container also includes a sealing assembly including a stopper extending over the sealing surface of the flange and a cap securing the stopper to the flange. The stopper has a glass transition temperature (T) that is greater than or equal to &#x2212;70&#xb0; C. and less than or equal to &#x2212;45&#xb0; C. The sealing assembly maintains a helium leakage rate of the sealed pharmaceutical container of less than or equal to 1.4&#xd7;10cm/s as the sealed pharmaceutical container is cooled to a temperature of less than or equal to &#x2212;45&#xb0; C.

Glass containers and sealing assemblies for maintaining seal integrity at low storage temperatures

Growing community of inventors

Painted Post, NY, United States of America

Adam Robert Sarafian