Windgap Medical, Inc.

Advanced Silicon Group, Inc.

Other

Mc10, Inc.

Bandgap Engineering, Inc.

Medidata Solutions, Inc.

Adam R Standley

Brent Alan Buchine

Jeffrey Thomas Chagnon

Cole Constantineau

Christopher Stepanian

Michel Bruehwiler

Robert Brik

Marcie R Black

Brian P Murphy

Michael Jura

Joanne Forziati

Jeff Ray Miller

Jeffrey B Miller

Joanne Yim

Brent Buchine

Yung-Yu Hsu

Mary Teresa Carter

Kaliappanadar Nellaiappan

Steven Fastert

Brian Elolampi

David G Garlock

Harold Gaudette

Ashritha Durvasula

Chris Stepanian

Ralph Navarro

Brent R Buchine

Zachery John Dusterhoft

Evan Sherr

Aaron Kapelus

Harry Gaudette

Mary Carter

Jeffreythomas Chagnon

Dave Garlock

Christoper J Stepanian

Christopher J Stepanian

An injector training device configured to mimic a real portable autoinjector mixing and delivery device including mimicking pressure required to twist the cap, various clicking noises, bump trigger, and the extension of the bump trigger that mimics a lockout needle shield. The injector training device is also configured to be resettable for multiple training sessions.

Autoinjector training device

The present disclosure provides methods of preparing a medical solution. In some aspects, the medical solution can be prepared from mixing a first liquid with a second liquid or mixing a solid component with a liquid in an autoinjector. In some aspects, the heat released from the mixing can promote solubility of a dry medicament in the solution.

Drug mixing and delivery system and method

A portable dual chamber auto-injector configured to store a dry opioid antagonist medicament separately from a liquid component, wherein a user actuated mixing system comprising a movable component to create a fluidic pathway between the first and second chambers and release a portion of energy from a pre-stored energy to drive a displacement mechanism into the first chamber and displace the liquid component into the second chamber and solubilize the opioid antagonist. A needle assembly in fluid communication with the second chamber can be used to transfer the solubilized opioid antagonist.

Portable drug mixing and delivery device and associated methods

A component storage and nest system, the system including a tub having a lip portion provided on an interior surface of the tub; a primary nest having a plurality of receptacles in an upper surface, the upper surface having a flange portion about a perimeter being configured to engage the tub about the lip portion; and a plurality of medical components, a medical component being provided in each of the plurality of receptacles.

System and method for providing and assembling an auto-injector

A mixing device configured to hold two containers, each having a separate medicament component disposed therein. A fluidic channel is provided that upon creating fluidic communication with each container once seals about each container are opened. Then a transfer mechanism can transfer the medicament components from one container to the other container until ready to be delivered or transferred through the fluidic channel through a delivery assembly.

Dynamic mixing and delivery system for mixing a therapeutic agent in an injector or autoinjector

The invention provides pharmaceutical compositions comprising a dry medicament. The dry medicaments can be rapidly dissolved, solubilized, and/or reconstituted to deliver to a subject. The present invention provides methods of preparing a medical solution. The medical solution can be prepared from mixing the pharmaceutical composition as described herein with a first liquid.

Method and compositions for dissolving or solubilizing therapeutic agents

The present invention relates to a mixing and injector device which can include: a housing having a plurality of separate and distinct chambers disposed therein; one or more displacement mechanisms corresponding to each of the plurality of chambers disposed within the housing; a needle assembly being provided about one of the plurality of chambers, the needle assembly including the following: a septum; a needle being separated from the plurality of chambers by the septum, the needle having a proximal end configured to pierce the septum in an actuated state; and a needle carrier, the needle carrier being configured to translate axially with respect to and toward the septum and pierce the septum and provide fluid communication from the plurality of chambers through the needle in the actuated state.

Mixing and injection device with sterility features

Contemplated herein is a medication mixing device which can include a housing having therein a first chamber containing a first medicament component and a second chamber provided containing a second medicament component provided with a sealing structure selectively isolating the first chamber from the second chamber. The sealing structure can include a first sealing component having a first sealing interface and a second sealing component having a second sealing interface wherein a first compression force can be applied to the first and second sealing components causes the sealing interfaces to form a seal. The first compression force can then be configured to allow the first sealing component and the second sealing component to maintain at least one degree of freedom with respect to one another.

Compression seal for use with a liquid component storage vial of an auto-injector

A portable auto-injector configured to store a dry medication separately from a liquid component, wherein removal of a cap operates a first actuation mechanism which opens a valve between a first and second chamber that are slidably movable relative to each other and thus allows for the initiation of a mixing step prior to injection. An extendable needle guard is provided over the delivery assembly which prevents premature injection as well as inadvertent sticks or other cross contamination of a needle. The needle guard can also form part of a secondary trigger mechanism which injects the mixed components after the mixing stage is complete.

A telescoping portable drug mixing and delivery device configured to store a dry medication separately from a liquid component, wherein a tensile force applied between the housing and a cap opens a valve and causes displacement of a fluid from a first chamber to a second chamber while simultaneously mixing the fluid with a dry medicament prior to injection. An extendable needle guard is provided over the delivery assembly which prevents premature injection as well as inadvertent sticks or other cross contamination of a needle. The needle guard can also form part of a secondary trigger mechanism which injects the reconstituted drug after the mixing stage is complete.

A portable auto-injector configured to store a liquid component in a first chamber separately from a dry medication in a second chamber, wherein a first actuation mechanism opens a valve allowing for the initiation of a mixing step prior to injection. An extendable needle guard is provided over the delivery assembly which prevents premature injection as well as inadvertent sticks or other cross contamination of a needle. The needle guard can also form part of a secondary trigger mechanism which injects the mixed components after the mixing stage is complete.

Encapsulated conformal electronic devices, encapsulated conformal integrated circuit (IC) systems, and methods of making and using encapsulated conformal electronic devices are presented herein. A conformal IC device is disclosed which includes a flexible substrate, electronic circuitry attached to the flexible substrate, and a flexible multi-part encapsulation housing encasing therein the electronic circuitry and flexible substrate. The multi-part housing includes first and second encapsulation housing components. The first encapsulation housing component has recessed regions for seating therein the electronic circuitry, while the second encapsulation housing component has recessed regions for seating therein the flexible substrate. First encapsulation housing component optionally includes a recessed region for seating therein the flexible substrate. Either housing component may include one or more projections that pass through holes in the substrate to engage complementary depressions in the other housing component to thereby align and interlock the encapsulation housing components with the flexible substrate and electronic circuitry.

Multi-part flexible encapsulation housing for electronic devices and methods of making the same

A removable cap for use with an auto-injector device, whereupon removal of the cap triggers an actuating assembly that can cause an automatic mixing of medicament components in an auto-injector device and/or place the auto-injector in a state to be used.

Removable actuating cap for use with an auto-injector assembly

Portable Drug Mixing and Delivery Device and Associated Methods

A portable auto-injector configured to store a dry medication separately from a liquid component, wherein removal of a cap opens a rotary valve allowing for the initiation of a mixing step prior to injection. An extendable needle guard is provided over the delivery assembly which prevents premature injection as well as inadvertent sticks or other cross contamination of a needle. The needle guard can also form part of a secondary trigger mechanism which injects the reconstituted drug after the mixing stage is complete.

Growing community of inventors

Cambridge, MA, United States of America

Adam R Standley