University of Illinois

Rhaeos, Inc.

Diagnostic Photonics, Inc.

Adam M Zysk

Stephen A Boppart

Freddy T Nguyen

Daniel L Marks

Adam L Gullickson

Michael Alan Fry

Siddharth Krishnan

Andrew J Cittadine

Steven G Adie

Charles William Weber

Simon C Schlachter

Matthew S Leigh

Julian J Armstrong

David D Sampson

John Charles Skelton

Brian Phillip Beaubien

Anna Lisa Somera

Flow sensor

A system for providing intraoperative feedback to a user during the course of surgery. A core imaging unit provides low-coherence optical radiation coupled to a sampling device and generates optical coherence tomography (OCT) data based on combining scattered light received from the sampling device together with a reference signal. The sampling device is adapted to receive the low-coherence optical radiation from the core imaging unit and to illuminate the tissue, and to collect light scattered by the tissue and to return said light to the core imaging unit. A core software unit receives the OCT data from the core imaging unit provides real-time feedback, such as an image, to the user via an indicator.

Low-coherence interferometry and optical coherence tomography for image-guided surgical treatment of solid tumors

Described herein are an apparatus and method by which at least one core specimen is obtained from a patient. The specimen is optionally placed on a tray, in a holder, or in another device designed to hold the tissue specimen; images of the specimens are acquired with optical coherence tomography, optical coherence tomography image data and, optionally, data from an additional imaging or analysis method, and when analyzed with the tissue classification process yield information on one or more of: the adequacy of the specimens obtained; the likelihood that they contain abnormal or malignant tissue; the regions and/or specimens most likely to contain diagnostic tissue; the approximate dimensions, area, or volume of the abnormal tissue; and the probable type of abnormality.

Method and apparatus for classifying core biopsy specimens with optical coherence tomography

A method of forming an image of tissue. The method includes beginning an invasive procedure on a patient exposing tissue. The method then includes acquiring OCT data from the exposed tissue and converting the OCT data into at least one image. The method also includes ending the invasive procedure after the converting of the data.

A system and method for microscale measurement and imaging of the group refractive index of a sample. The method utilizes a broadband confocal high-numerical aperture microscope embedded into an interferometer and a spectrometric means, whereby spectral interferograms are analyzed to compute optical path delay of the beam traversing the sample as the sample is translated through the focus of an interrogating light beam. A determination of group refractive index may serve to disambiguate phase ambiguity in a measurement of refractive index at a specified wavelength. Spatial resolution of object characterization in three dimensions is achieved by imaging the object from multiple viewpoints.

Group refractive index reconstruction with broadband interferometric confocal microscopy

A method of analyzing tissue includes inserting a radiation source into tissue, impinging radiation upon the tissue, obtaining a sample signal of the radiation that impinges upon the tissue, and determining a refractive index of the tissue from the sample signal. The method may also include determining at least one other optical property of the tissue. The method may provide for identifying tissue as part of a biopsy method. A device for analyzing tissue may include a low-coherence interferometer and a probe optically coupled to the interferometer, where the probe includes a radiation source.

Method and apparatus for measurement of optical properties in tissue

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Chicago, IL, United States of America

Adam M Zysk