Allergan, Inc.

Adam L Collette

Gregory H Altman

Jingsong Chen

Dennis E Van Epps

Wha Bin Im

Wha-Bin Im

Rebecca L Horan

Guang-Liang Jiang

Jing Song Chen

Rebeca L Horan

The present specification provides for methods for purifying fibroins, purified fibroins, methods of conjugating biological and synthetic molecules to fibroins, fibroins conjugated to such molecules, methods of making fibroin hydrogels, fibroin hydrogels and fibroin hydrogel formulations useful for a variety of medical uses, including, without limitation uses as bulking agents, tissue space fillers, templates for tissue reconstruction or regeneration, cell culture scaffolds for tissue engineering and for disease models, surface coating to improve medical device function, or drug delivery devices.

Silk fibroin hydrogels and uses thereof

The specification discloses compositions and methods for treating a soft tissue defect of an individual.

Compositions and soft tissue replacement methods

The invention relates to compositions comprising a silk fibroin material, adipose tissue and a compound of the structure where Xand Xare independently CH or N; Xis NH, O or S; Xand Xare independently CH or N; Ris an optionally substituted aryl or optionally substituted heteroaryl and Ris Calkyl, optionally substituted aryl or optionally substituted heteroaryl. The composition is administered to a site of a soft tissue condition including those of breast tissue. The silk fibroin material can be in the form of a silk hydrogel, a silk film, a silk scaffold, a silk sheet, a silk porous material or a silk fiber. The silk fibroin material can be substantially sericin free.

The invention relates to compositions comprising adipose tissue, a silk fibroin material and a compound of the structure The composition is administered to a site of a soft tissue condition including those of breast tissue. The silk fibroin material can be in the form of a silk hydrogel, a silk film, a silk scaffold, a silk sheet, a silk porous material, a silk fiber or a combination of those materials. The silk material may be substantially sericin free.

The present specification provides compositions useful as dermal fillers and methods using such compositions to treat a condition of skin.

Growing community of inventors

Westminster, MA, United States of America

Adam L Collette