Electro-optical Sciences, Inc.

Adam Jacobs

Tomasz Momot

Marek Elbaum

Michael Greenebaum

Dina Gutkowicz-Krusin

Alexandru Bogdan

Sunguk Keem

Nikolai Kabelev

Theodore S Shultz

Allen H Schneiderman

Data corresponding to biological tissue or lesions imaged in a remote location are communicated automatically to a central location, where the data are analyzed using data and algorithms stored securely at the central location. A result of the analysis is communicated from the central location to the remote location. Payment to an entity associated with the central location is made for each image or set of images.

Method of controlling data gathered at remote locations

A method, apparatus, and system for accounting for dark current in the output of an imaging array is presented. A dark current monitor on the monolithic semiconductor imaging array is provided. The dark current monitor may be darkened pixels of the imaging array, darkened pixels of another array, or a temperature monitor and associated circuitry necessary to calculate relative dark current from the monitored temperature.

Integrated CMOS imaging array dark current monitor

An apparatus for holding an optical system in a reproducible position with respect to a tooth in a mouth is presented. The apparatus has a body with a light source attached to a prong by a spring, and the prong contacts the proximal surface of the tooth.

Apparatus for holding optical instruments in a reproducible position with respect to teeth

A set of lens elements is assembled to form a lens by adjusting a first and a second lens element in a spaced apart optical relationship with respect to each other, then affixing the two elements in the spaced apart optical relationship by affixing a lens element holder to at least the second lens element. Further lens elements are assembled in turn and affixed in spaced apart optical relationship to the preceding lens elements to form a finished lens.

Method for assembling lens elements

An means for blocking light reflected from the surface of a tooth from the imaging system while imaging light transilluminated through the tooth is presented.

Method of transillumination imaging of teeth

A method, apparatus, and system for uniform illumination of an object is presented. A plurality of light sources is adjusted relative to a base in order to give a defined illumination pattern with respect to the base. Then, the light sources are rigidly affixed to the base.

Apparatus for uniform illumination of an object

An elastomeric locator held against a proximal surface of the tooth and against the gum holds a light source and imaging optics in a reproducible position for imaging a tooth in vivo.

A light image is conveyed from a biological tissue through a flexible optical system to an image receiver, where it is converted to a form which may be entered into a computer. The computer segments the image by generating a segmentation mask defining the boundary of a region of interest in at least one spectral band, estimates at least one rotationally and translationally invariant statistical measure of coefficient distributions of the multiscale wavelet maxima representations of the digital images in at least one spectral band, characterizes the condition of the tissue based on the estimated values, and outputs the characterization of the condition of the tissue.

Multispectral imaging and characterization of biological tissue

An injection molded light pipe having a sharp curve is proposed, wherein the injection molding mark is on the inside surface of the sharp curve. The light pipe has a 180&deg; curve with a radius of curvature less than approximately 3 times the diameter of the light pipe.

Injection molded light pipe

Systems and methods for the multispectral imaging of skin tissue enables automatic characterization of the condition of a region of interest of the skin, based on direct digital imaging of the region of interest or the digitization of color photographic slides of the region of interest, illuminated by appropriately filtered light. Preferably, a digital image at a low spectral band is automatically segmented and that segmented mask is used to segment the other images by a digital processor. Parameters related to the texture, asymmetry, blotchiness and border irregularities are also automatically estimated. The region of interest is automatically characterized by the digital processor, based on those parameters. The region of interest may include a skin lesion, in which case the present invention enables the characterization of the lesion as malignant or benign.

Systems and methods for the multispectral imaging and characterization of skin tissue

A method and apparatus for imaging teeth includes illuminating a surface of a tooth and electronically imaging the tooth from a non-illuminated surface of the tooth with an electronic camera. Automatic control of the intensity of illumination is preferably provided to avoid saturation of the camera. The camera may include a charge-coupled-device and the resulting digital images are preferably enhanced by wavelet analysis. If a video camera is used, the images may be digitized and then enhanced. Current images of the tooth may be compared to prior images of the same tooth to monitor changes in the tooth over time. The images can be used to detect dental caries and other dental conditions. A handpiece for illuminating the tooth and receiving the light passing through the tooth for reception by the camera in a reproducible manner, is also described.

Method and apparatus for electronically imaging a tooth through transillumination by light

Systems and methods for the multispectral imaging of skin tissue enables automatic characterization of the condition of a region of interest of the skin, based on direct digital imaging of the region of interest or the digitization of color photographic slides of the region of interest, illuminated by appropriately filtered light. Preferably, a digital image at a low spectral band is automatically segmented and that segmented mask is used to segment the other images by a digital processor. Parameters are estimated through wavelet maxima representations. Parameters related to the texture, asymmetry, blotchiness and border irregularities are also automatically estimated. The region of interest is automatically characterized by the digital processor, based on those parameters. The region of interest may include a skin lesion, in which case the present invention enables the characterization of the lesion as malignant or benign. The region of interest may also include wounds or burns.

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Woodcliff Lake, NJ, United States of America

Adam Jacobs