Perkinelmer Health Sciences, Inc.

The Perkin-elmer Corporation

Perkinelmer Instruments LLC

Adam J Patkin

Rosario Mannino

Keith Ferrara

David Barkus

Frank DeLorenzo

Barton Rasmussen

Daniel Pentek

Andrew Tipler

David H Tracy

David G Welkie

Jerry E Cahill

Michael I Crockett

Andrew P Bajorinas

Ralph L Carter

Andrew J Bajorinas

Ralph Carter

Frank Delorenzo

Certain configurations of an ionization source comprising a multipolar rod assembly are described. In some examples, the multipolar rod assembly can be configured to provide a magnetic field and a radio frequency field into an ion volume formed by a substantially parallel arrangement of rods of the multipolar rod assembly. The ionization source may also comprise an electron source configured to provide electrons into the ion volume of the multipolar rod assembly to ionize analyte introduced into the ion volume. Systems and methods using the ionization source are also described.

Ionization sources and methods and systems using them

Certain embodiments described herein are directed to devices that can be used to align the components of a source assembly in a source housing. In some examples, a terminal lens configured to couple to the housing through respective alignment features can be used to retain the source components in a source housing to provide a source assembly.

Assemblies for ion and electron sources and methods of use

A thermionic electron source comprises a nonlinear metallic substrate, a coating of yttria deposited on the substrate, and a current source configured to drive current through the metallic substrate.

YTTRIA-metal thermionic filaments

An array of ion detectors (,) comprising a plurality of pickup electrodes (,) for receiving ions; a substrate (,); a plurality of insulators (,) positioned respectively between said pickup electrodes (,) and said substrate (,); a plurality of charge storage areas (,) for storing charge received by said pickup electrodes (,), wherein each area (,) is connected to a particular pickup electrode (,) and means (,) for determining the amount of charge collected by each charge storage area.

Ion detector, detector array and instrument using same

A primary chromatographic system is operated with a standard sample at several temperatures to generate primary retention times which are fitted to a function to determine thermodynamic constants to relate the times to temperature. A target chromatographic system is operated with the standard sample to generate secondary retention times. The function is used with these times to determine and an effective column parameter for the target system. The function then is used with this parameter and the primary times to determine a pressure program. Further operation of the target system with a application sample and the pressure program effects standardized retention times. A particular searching technique is utilized to apply the function. A temperature calibration technique with a selected sample measures column temperature for the target system, and a validation is done on the target system.

Standardization of chromatographic systems

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Hamden, CT, United States of America

Adam J Patkin