Hewlett-packard Development Company, L.p.

Adam Higgins

Alexander N Govyadinov

Michael W Cumbie

Pavel Kornilovich

Erik D Torniainen

Hilary Ely

Rachel M White

Chien-Hua Chen

Viktor Shkolnikov

Jeffrey Allen Nielsen

George H Corrigan

Chantelle Domingue

Michael J Day

Tod Woodford

A fluid thermal processing device may include a substrate, a platform projecting from the substrate, a fluid heating element supported by the platform, a temperature sensing element, distinct from the fluid heating element, supported by the platform and an enclosure supported by and cooperating with the substrate to form a fluid chamber about the platform. The fluid chamber forms a volume of uniform thickness conforming to and about the platform.

Fluid thermal processing

A nucleic acid amplifier may include a sample preparation zone, a fluid ejector, an amplification zone and a capillary break between the amplification zone and the fluid ejector.

Nucleic acid amplification

The present disclosure is drawn to microfluidic devices. A microfluidic device can include a substrate, a lid mounted to the substrate, and a microchip mounted to the substrate. The lid mounted to the substrate can form a discrete microfluidic chamber between structures including an interior surface of the lid and a portion of the substrate. The lid can include an inlet and a vent positioned relative to one another to facilitate loading of fluid to the discrete microfluidic chamber via capillary action. A portion of the microchip can be positioned within the discrete microfluidic chamber.

Microfluidic devices with lid for loading fluid

A system for partitioning a liquid sample, the system including: an ejection device, the ejection device including an array of nozzles, wherein adjacent nozzles are separated by a constant distance in a first axis; and a microfluidics device including: a plurality of intake ports to receive a deposited droplet, wherein pairs of intake ports are separated by the same constant distance in the same first axis such that adjacent nozzles can simultaneously eject droplets to different intake ports.

Partition liquid into samples

The viscosity of a fluid may be determined using a flow rate determination. The flow rate may be determined based on fluid presence determinations within a capillary channel. Also, a temperature of an environment surrounding a capillary channel may be determined and signals may be transmitted to a thermal element responsive to the determined temperature.

Determine viscosity of fluids using a capillary channel

The present disclosure is drawn to microfluidic devices. In one example, a microfluidic device can include a first covered fluid feed slot in fluid communication with a first microfluidic channel and a second covered fluid feed slot in fluid communication with a second microfluidic channel. The first microfluidic channel can be formed adjacent to the second microfluidic channel but not in fluid communication with the second microfluidic channel. The first covered fluid feed slot can include a first fluid feed hole for filling a fluid into the first covered fluid feed slot. The second covered fluid feed slot can also include a second fluid feed hole for filling a fluid into the second covered fluid feed slot.

Microfluidic devices

The present disclosure is drawn to microfluidic devices. In one example, a microfluidic device can include a driver chip and a fluid chamber located over the driver chip. First and second microfluidic loops can have fluid driving ends and fluid outlet ends connected to the fluid chamber. The first and second microfluidic loops can include a portion thereof located outside a boundary of the driver chip. A first fluid actuator can be on the driver chip associated with the fluid driving end of the first microfluidic loop to circulate fluid through the first microfluidic loop. A second fluid actuator can be on the driver chip associated with the fluid driving end of the second microfluidic loop to circulate fluid through the second microfluidic loop.

Temperature-controlling microfluidic devices

The present disclosure is drawn to temperature-cycling microfluidic devices. In one example, a temperature-cycling microfluidic device can include a driver chip having a top surface and a heat exchange substrate having a top surface coplanar with the top surface of the driver chip. A fluid chamber can be located on the top surface of the driver chip. A first and second microfluidic loop can have fluid driving ends and fluid outlet ends connected to the fluid chamber and can include portions thereof located on the top surface of the heat exchange substrate. A first and second fluid actuator can be on the driver chip. The first and second fluid actuators can be associated with the fluid driving ends of the first and second microfluidic loops, respectively, to circulate fluid through the first and second microfluidic loops.

Temperature-cycling microfluidic devices

The present disclosure is drawn to microfluidic devices. In one example, a microfluidic device can include a microfluidic channel. A vent chamber can be in fluid communication with the microfluidic channel. A capillary break can be located between the microfluidic channel and the vent chamber. The capillary break can include a tapered portion and a narrowed opening with a smaller width than a width of the microfluidic channel. A vent port can vent gas from the vent chamber. The vent port can be located a distance away from the capillary break so that a fluid in the capillary break does not escape through the vent port.

Growing community of inventors

Corvallis, OR, United States of America

Adam Higgins