Pfizer Corporation

Adam Gillmore

Eleftherios Kougoulos

Patricia Ann Basford

Anthony Michael Campeta

Suman Luthra

Robert Walton

Matthew Cameron Jones

Donald Stuart Middleton

Alan Stobie

David Cameron Pryde

Andrew Simon Cook

Stephen Challenger

The present invention relates to novel polymorphic forms of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one, and to processes for their preparation. Such polymorphic forms may be a component of a pharmaceutical composition and may be used to treat a mammalian disease condition mediated by poly(ADP-ribose) polymerase activity including the disease condition such as cancer.

Salts and polymorphs of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one

Salts and polymorphs of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6h-azepino[5,4,3-cd]indol-6-one

The invention relates to compounds of formula (I) for treating for example sexual dysfunction, wherein Ris optionally substituted Calkyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, hydrogen, Calkoxy, &#x2014;NRRor &#x2014;NRSOR; X is the linkage &#x2014;(CH)&#x2014; or &#x2014;(CH)&#x2014;O&#x2014; (wherein Y is attached to the oxygen); wherein one or more hydrogen atoms in linkage X may be replaced independently by Calkoxy; hydroxy; hydroxy(Calkyl); Ccycloalkyl; carbocyclyl; heterocyclyl; or by Calkyl optionally substituted by one or more fluoro or phenyl groups; n is 3, 4, 5, 6 or 7; and q is 2, 3, 4, 5 or 6; and Y is phenyl or pyridyl, each of which may be substituted; or two Rgroups on adjacent carbon atoms together with the interconnecting carbon atoms may form a fused optionally substituted 5- or 6-membered carbocyclic or heterocyclyic ring.

N-phenpropylcyclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase

The invention relates to compounds of formula (I) for treating for example sexual dysfunction, wherein R is optionally substituted C alkyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, hydrogen, C alkoxy, &mdash;NR R or &mdash;NR SO R ; X is the linkage &mdash;(CH ) &mdash; or &mdash;(CH ) &mdash;O&mdash; (wherein Y is attached to the oxygen); wherein one or more hydrogen atoms in linkage X may be replaced independently by C alkoxy; hydroxy; hydroxy(C alkyl); C cycloalkyl; carbocyclyl; heterocyclyl; or by C alkyl optionally substituted by one or more fluoro or phenyl groups; n is 3, 4, 5, 6 or 7; and q is 2, 3, 4, 5 or 6; and Y is phenyl or pyridyl, each of which may be substituted; or two R groups on adjacent carbon atoms together with the interconnecting carbon atoms may form a fused optionally substituted 5- or 6-membered carbocyclic or heterocyclyic ring.

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Sandwich, United Kingdom

Adam Gillmore