Pepsico, Inc.

Nanologica Ab

Adam Feiler

Peter S Given

Varda Shoshan-Barmatz

Hans Lennernäs

Robert Corkery

Eapen George

Julie Anne Grover

Chris Dimelow

Sergey V Dvinskikh

Istvan Furo

Pavel V Yushmanov

Xin Xia

Chunfang Zhou

Paulina Paszkiewicz

Adrian Israelson

Elena Kozlova

Nerea Arriaga Garcia

The present invention relates to a process for manufacturing porous silica particles comprising at least one bioactive compound, whereby the particles are adapted for lung, nasal, sublingual and/or pharyngeal delivery of said at least one bioactive compound and have an MMAD between 0.5 and 15 &#x3bc;m with a GSD less than 2.5. The invention also relates to a pharmaceutical composition comprising said silica particles and a use of the silica particles in the diagnoses, prevention and/or treatment of local and/or systemic disorders, such as disorders of the lung, nose, sublingual and/or pharynx.

Process for manufacturing porous silica particles loaded with at least one bioactive compound adapted for lung, nasal, sublingual, and/or pharyngeal delivery

Methods for measuring physico-chemical properties using a nuclear magnetic resonance spectrometer are disclosed, including methods to determine an initial amount of a substance, usually a liquid, contained inside a porous material and an initial amount of the substance, usually a liquid, present outside the porous material, methods to measure the release kinetics of a substance, such as a liquid, from a porous material, and methods for performing chemical reactions and other physico-chemical operations in situ inside a nuclear magnetic resonance probe after a sample is loaded into a nuclear magnetic resonance spectrometer. The apparatuses for performing these methods are also disclosed.

Method and apparatus for measuring physico-chemical properties using a nuclear magnetic resonance spectrometer

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Hässelby, Sweden

Adam Feiler