Nano Precision Medical, Inc.

Adam D Mendelsohn

Kathleen E Fischer

Wouter Erik Roorda

Tomoyuki Yoshie

Au Duong

William G M Fischer

Adam Monkowski

Lily H Peng

William G Fischer

Embodiments of the invention include devices, compositions and methods for the controlled release of therapeutic substances, such as drugs. Control over the rate of release of the therapeutic substances from the devices is achieved by the use of nanoporous membranes in which the pore size is matched to the molecular diameter of the therapeutic substances. Some embodiments of the invention achieve zero-order release by the use of membranes with a pore diameter that is more than five times the Stokes' diameter of the therapeutic substance released.

Drug delivery device

The present invention provides compositions of a therapeutic agent and a polymeric stabilizing agent for stabilizing the reservoir of an implantable drug delivery system. The present invention also includes an implantable drug delivery system incorporating the composition of the present invention, as well as methods of treating diabetes using the compositions and implantable drug delivery system of the present invention.

Polymeric stabilizing formulations

The invention pertains to apparatuses, means and methods to promote uptake of fluids into a reservoir of an implantable drug delivery system though a porous membrane. Embodiments of the invention promote fluid uptake by creating a pressure differential between the reservoir of the drug delivery device and the environment of the device after implantation, for instance a subcutaneous pocket.

Apparatus and method for promoting fluid uptake into an implant

The present invention provides a device including a titania nanotube membrane having a plurality of titania nanotubes on a titanium substrate where the titania nanotubes are open at both ends and capable of allowing diffusion of liquids or solids from one side of the membrane to the other through the titania nanotubes. Methods of making the titania nanotube membrane are also provided.

Device having titania nanotube membrane for drug delivery

The present invention provides a method for controlling the internal diameter of nanopores to afford nanopore membranes with a zero-order rate of release of a therapeutic agent.

Growing community of inventors

Emeryville, CA, United States of America

Adam D Mendelsohn