New York University

Northwestern University

The City University of New York

Texas Tech University System

Adam B Braunschweig

Chad A Mirkin

Xing Liao

Shudan Bian

Anjali Joshi

Himanshu Garg

Jinan Chai

Milan A Shlain

Kalanidhi Palanichamy

Stephen Rieth

M Fernando Bravo

Zijian Zheng

Gengfeng Zheng

Xiao Zhong

Louise R Giam

Wooyoung Shim

Charlotte E Hinkle

Dan J Eichelsdoerfer

Lu Shin Wong

Jong Kuk Lim

Kevin B Schesing

Matthew Miner

Zhong Li

Compounds with anti-viral properties are provided that are based on the following structures: A variety of heteroaromatic groups have been found to be biologically active against viral infections. In some embodiments, a dimeric compound is provided with each monomer linked by a repeating glycol linking group.

Carbohydrate-binding small molecules with antiviral activity

Compounds with anti-viral properties are provided that are based on the following structures:  A variety of heteroaromatic groups have been found to be biologically active against the Zika (ZIKV) virus. In some embodiments, a dimeric compound is provided with each monomer linked by a repeating glycol linking group.

The present invention relates generally to molecular printing techniques for use in sensors, assays, and integrated optics and electronics. Specifically, the present invention relates to covalent patterning of graphene surfaces.

Covalently patterned graphene surfaces by a force accelerated cycloaddition reaction

Polymer Pen Lithography materials that retain the simplicity characteristic for the fabrication of poly(dimethyl siloxane) tip arrays while preserving the control over feature dimensions and to understand the role of the mechanical properties of the different materials on Polymer Pen Lithography printing.

Systems and methods for polymer tips using silanated supports

The present invention relates generally to molecular printing techniques for use in sensors, arrays, and integrated optics and electronics. The invention features described give rise to the ability to immobilize biological probes by force-induced patterning, while still maintaining the conductivity of the graphene substrate. Most particularly, the present invention relates to covalent patterning of graphene surface using a force-accelerated reaction.

The present invention is directed to a new class of synthetic carbohydrate receptor compounds comprising Formula I as described herein: (I). Other aspects of the present invention relate to pharmaceutical compositions and pharmaceutical delivery vehicles comprising the compound of Formula (I) The present invention is also directed to methods of treatment and diagnosis that involve the administration of a compound of Formula (I). 

Carbohydrate-selective receptors

A quantitative model that describes the assembly of diketopyrrolopyrrole-based donors and a perylenediimide acceptor into chiral superstructures, as a result of both hydrogen bonding and &#x3c0;&#x2022;&#x2022;&#x2022;&#x3c0; stacking. This model provides thermodynamic parameters (&#x394;H&#xb0; and &#x394;S&#xb0;) for all noncovalent interactions involved in the assembly and explains the subtle supramolecular cues that convert disordered aggregates into well-defined helical assemblies.

Superstructures of diketopyrrolopyrrole donors and perylenediimide acceptors formed by hydrogen-bonding and &#x3c0;&#x2022;&#x2022;&#x2022;&#x3c0; stacking

Disclosed are methods of lithography using a tip array having a plurality of pens attached to a backing layer, where the tips can comprise a metal, metalloid, and/or semi-conducting material, and the backing layer can comprise an elastomeric polymer. The tip array can be used to perform a lithography process in which the tips are coated with an ink (e.g., a patterning composition) that is deposited onto a substrate upon contact of the tip with the substrate surface. The tips can be easily leveled onto a substrate and the leveling can be monitored optically by a change in light reflection of the backing layer and/or near the vicinity of the tips upon contact of the tip to the substrate surface.

Silicon pen nanolithography

The disclosure relates to a method of forming a pattern having pattern elements with a plurality of sizes on a substrate surface with a tilted pen array that includes choosing a tilt geometry for a pen array with respect to a substrate, inducing the tilt geometry between the pen array and the substrate surface, and forming a pattern having pattern elements on the substrate surface with the titled pen array, whereby the size of the formed pattern elements varies across the substrate surface along the tilted axis or axes. For example, the tilt geometry is in reference to the substrate surface and comprises a first angle with respect to a first axis of the substrate and a second angle with respect to a second axis of the substrate, the second axis being perpendicular to the first axis, and at least one of the first and second angles being non-zero.

Generation of combinatorial patterns by deliberate tilting of a polymer-pen array

A method of leveling a polymer pen array includes contacting a pen array with a surface and measuring a total force exerted on the surface by the pen array, the pen array being disposed at a first angle with respect to a first axis of the surface and a second angle with respect to a second axis of the surface; tilting one or both of the pen array and the surface to vary the first and second angles of the pen array with respect to the surface; measuring the total force exerted by the tilted pen array on the surface; and repeating the tilting and measuring steps until a global maximum of the total force exerted on the surface by the pen array is measured, thereby determining first and second angles which correspond to a leveled position of the pen array with respect to the surface.

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New York, NY, United States of America

Adam B Braunschweig