United States of America, As Represented by the Secretary of Agriculture

Louisiana State University and Agricultural & Mechanical College

Merial Limited

Aventis Agriculture Limited

Rhone-poulenc Agro

Adalberto A Perez De Leon

Felicito Guerrero

David Teh-Wei Chou

Robert A Miller

Stefan Schnatterer

Hyoung Ik Lee

Philip Reid Timmons

Jamin Huang

Karl Seeger

Fred M Tatum

Robert E Briggs

Uwe Döller

Andrew Scribner

Lane D Foil

Anke Kuhlmann

Maria-Theresia Thönessen

William Glenn Cawthorne, Jr

Loïc Patrick Le Hir De Fallois

Henricus Maria Martinus Bastiaans

Scot Kevin Huber

Yves Ribeill

Susan Marie McComb

Michael James Malaska

Andrew Y Li

Henricus Maria Marinus Bastiaans

Pamela J Ferro

Joseph J Modarelli

Maria D Esteve-gasent

Kits, methods, and material for use in detecting tick-borne microorganism(s) are provided herein. One is able to detect DNA from several different species of microorganisms from samples (bodily fluid, tissue, etc.) from ticks and/or mammals to determine if one or more of the microorganisms has infected the tick and/or mammal. The assay uses PCR techniques with a multiple primers and probes. The microorganisms can be in the Borrelial Layer, the Rickettsiales Layer, and/or the Babesial Layer.

Assays for detecting multiple tick-borne pathogens

This invention relates to novel fusion peptides and immunogenic compositions containing the fusion peptides useful in the control and prevention of tick infestations. The invention also relates to compositions comprising said fusion peptides, methods of vaccination against tick infestation using said fusion peptides and compositions, and kits for use with such compositions and methods.

Southern cattle tick vaccine product

Compositions of either the Rm86Texas protein from a Texas outbreak strain of the southern cattle fever tick,, or a nucleic acid construct incorporating a nucleic acid sequence encoding this Rm86Texas protein, are effective for eliciting a protective immune response in non-bovine animals. The Rm86Texas protein is immunogenic and can be administered as a protein vaccine, or in the alternative, the nucleic acid construct can be utilized as a DNA vaccine. Induction of the immune response significantly reduces or eliminates the infestation of treated, non-bovine animals with ticks. Moreover, as ticks are vectors of a variety of pathogens, the reduction in the incidence of tick infestation afforded by the vaccines may concurrently reduce the incidence of diseases caused by these pathogens in susceptible animals.

Vaccination with anti-tick antigens to control multiple tick species and disease transmission in white-tailed deer and other host animals

Two antigenic and immunogenic proteins of the cattle tick,, and the genes encoding these proteins, are effective for eliciting a protective immune response that controls and prevents infestations of bovines and other livestock by the tick. The proteins isolated from the cattle tick include an aquaporin protein and a TC5777 gut membrane protein. Each of the proteins elicit an immunoprotective response in livestock to the cattle tick, and can be formulated and administered as vaccines. Alternatively, the isolated DNA sequences which encode these proteins can be incorporated into nucleic acid constructs which could be utilized as DNA vaccines. The nucleic acid constructs can also be used for the transformation of cells and the production of recombinant proteins. Induction of the protective immune response controls and prevents infestations of the treated animals with the tick, thereby protecting them against tick-borne pathogen transmission.

Vaccination of animals to elicit a protective immune response against tick infestations and tick-borne pathogen transmission

Compositions of either the aquaporin protein from the cattle tick,, or a nucleic acid construct incorporating a nucleic acid sequence encoding this aquaporin protein, are effective for eliciting a protective immune response against other tick species in non-bovine animals. Theaquaporin protein is antigenic and can be administered as a protein vaccine, or in the alternative, the nucleic acid construct can be utilized as a DNA vaccine. Induction of the immune response significantly reduces or eliminates the infestation of treated, non-bovine animals with ticks other than the cattle tick, particularly the brown dog tick,. Moreover, as ticks are vectors of a variety of pathogenic agents, the reduction in the incidence of tick infestation afforded by the vaccines may concurrently reduce the incidence of diseases caused by these pathogenic agents in susceptible animals.

Vaccination of companion animals to elicit a protective immune response against tick infestations and tick-borne pathogen transmission

Provided are 1-aryl-5-alkyl pyrazole compounds, of formula (I): wherein: Ris hydrogen, cyano, halogen, R, formyl, &#x2014;C(O)R, &#x2014;C(O)OR, &#x2014;C(O)NRR, or &#x2014;C(S)NH; Ris Ror &#x2014;S(O)R; Ris methyl, ethyl or C-Chaloalkyl; R, Rand Rare independently hydrogen, halogen, alkyl, haloalkyl, cyano or nitro; Ris halogen, alkyl, haloalkyl, alkoxy, haloalkyloxy, cyano, nitro, &#x2014;C(O)R, &#x2014;S(O)Ror SF; Z is a nitrogen atom or C&#x2014;R; Ris alkyl, haloalkyl, cycloalkyl or halocycloalkyl; Ris hydrogen, alkyl, haloalkyl or alkoxy; Ris hydrogen, alkyl, haloalkyl or alkoxy; Ris alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl or cycloalkyl; Ris alkyl or haloalkyl; Ris hydrogen, halogen, cyano, nitro, alkyl, haloalkyl, alkoxy or haloalkoxy; m is 0, 1 or 2; and n is 0, 1 or 2; or a salt thereof, the method of making compounds of formula (I) and the use of these compounds against ectoparasites, endoparasites and pests.

1-aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof

The invention relates to the use for the control of pests, of a compound which is a 5-substituted-alkylaminopyrazole derivative of formula (I) or a salt thereof: wherein the various symbols are as defined in the description, to novel 5-substituted-alkylaminopyrazole derivatives and pesticidal compositions thereof, and to processes for their preparation. 

5-substituted-alkylaminopyrazole derivatives as pesticides

The invention relates to the use for the control of parasites in animals, of a compound which is a 5-substituted-alkylaminopyrazole derivative of formula (I) or a salt thereof: wherein the various symbols are as defined in the description, to novel 5-substituted-alkylaminopyrazole derivatives and pesticidal compositions thereof, and to processes for their preparation. 

A method of controlling parasites in or on an animal comprising orally administering to the animal a parasiticidally effective, substantially non-emetic 1-arylpyrazole.

Control of arthropods in animals

Growing community of inventors

Wake Forest, NC, United States of America

Adalberto A Perez De Leon