Ribovax Biotechnologies S.a.

Other

Ada Funaro

Santo Landolfo

Giorgio Gribaudo

Gianni Garotta

Vittorio Enrico Avvedimento

Mariarosaria Santillo

Armando Gabrielli

Marianne Murphy

Silvia Svegliati Baroni

Gianluca Moroncini

Roberto Paterno′

The present invention refers to peptides comprised in the extracellular region of human PDGF receptor (hPDGFR) alpha, their use for detecting auto-antibodies anti-hPDGFR alpha and to a method for the diagnosis or the monitoring control for therapy of SSc. The present invention also refers to antibodies or recombinant or synthetic derivatives thereof able to recognize and bind to the above peptide and to their use in the treatment of SSc.

Epitopes of the human PDGF receptor able to bind human auto-antibodies, antibodies and uses thereof

The present Invention provides novel methods for immortalizing cells that secrete antibodies of one or more specific isotypes. Polyclonal, oligoclonal, and monoclonal populations of cells obtained using the methods of the Invention can be screened on the basis of the functional and/or binding activities of the antibodies they secrete, for example directed to antigens of human or viral origin having medical interest, in cell culture conditions. Using these methods, human B cells that secrete antibodies binding human Cytomegalovirus, Herpes Simplex Virus, or HSP60 protein have been efficiently immortalized with Epstein-Barr virus.

Methods for obtaining immortalized antibody secreting cells

The present invention provides novel antibody sequences that bind human cytomegalovirus (hCMV) and neutralize hCMV infection. The novel sequences can be used for the medical management of hCMV infections, in particular for preparing pharmaceutical compositions to be used in the prophylactic or therapeutic treatment of hCMV infections.

Antibodies against human cytomegalovirus (HCMV)

Antibodies against human cytimegalovirus (HCMV)

Growing community of inventors

Turin, Italy

Ada Funaro