Farmitalia Carlo Erba S.p.a.

Other

Ada Buttinoni

Gianfederico Doria

Carlo Passarotti

Giuliana Arcari

PierNicola Giraldi

Pier P Lovisolo

Raffaele Tommasini

Willy Logemann

Giuliano Nannini

Giovanni Biasoli

The present invention relates to new condensed benzopyrone derivatives having a 5-tetrazolyl substituent thereon, and to pharmaceutical compositions containing them. The compounds are useful in the treatment of allergic conditions.

Condensed benzopyrone derivatives

The present invention relates to new condensed benzopyrone derivatives, to a process for their preparation and to pharmaceutical compositions containing them.

Pharmacologically active thiazolo[3,2-a]pyrimidines of the formula ##STR1## wherein A is a bond between the .alpha.- and .beta.-carbon atoms or (--CH.sub.2 --) group; R.sub.1 and R.sub.2 represent hydrogen, C.sub.1 -C.sub.4 alkyl, cyano, CF.sub.3, thienyl, pyridyl, biphenyl, naphtyl, phenyl optionally substituted, ##STR2## wherein R' and R' are hydrogen or alkyl; R.sub.3 represents hydrogen, halogen, alkyl, OH, formyloxy, alkanoyloxy, alkenyloxy; R.sub.4 represents substituted pyrrole, substituted phenyl or substituted thiazolyl. The compounds have antiinflammatory, antiulcerorgenic and antigastric secretory activity.

Substituted thiazolo[3,2-a]pyrimidines and process for their preparation

Compounds of the formula (I) ##STR1## wherein R.sub.1 is

Substituted 1,3,4-thiadiazolo[3,2-A]pyrimidines and compositions

The present invention relates to new carboxamido-derivatives of 5H-1,3,4-thiadiazolo[3,2-a]pyrimidines, to a process for their preparation and to pharmaceutical (i.e. anti-inflammatory and analgesic) compositions containing them. The invention provides compounds having the following general formula (I) ##STR1## wherein R.sub.1 represents:

Carboxamido-derivatives of 5H-1,3,4-thiadiazolo[3,2-a]pyrimidines,

Compounds of the formula (1) ##STR1## wherein n is 1 or 2;

Condensed cycloaliphatic derivatives of substituted

Compounds of general formula (I) ##STR1## wherein R.sub.1 is a 2-pyridyl, 3-pyridyl or 4-pyridyl group; (b) a phenyl ring, unsubstituted or substituted by one or two groups chosen from halogen, trihalo-C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.6 alkyl, nitro, amino and C.sub.2 -C.sub.6 alkanoylamino; (c) benzyl; or (d) C.sub.1 -C.sub.6 alkyl;

Substituted 1H-pyrazolo (1,5-a) pyrimidines and process for their

Pharmacologically active thiazolo[3,2-a]pyrimidines of the formula ##STR1## wherein A is a bond between the .alpha. and .beta.-carbon atoms or (--CH.sub.2 --) group; R.sub.1 and R.sub.2 represent hydrogen or halogen, C.sub.1 -C.sub.4 alkyl, cyano, CF.sub.3, thienyl, pyridyl, biphenyl, naphtyl, phenyl optionally substituted, ##STR2## wherein R' and R' are hydrogen or alkyl; R.sub.3 represents hydrogen, halogen, alkyl, OH, formyloxy, alkanoyloxy, alkenyloxy; R.sub.4 represents pyridyl optionally substituted by alkyl. The compounds have antiinflammatory, antiulcerogenic and anti-gastric secretory activity.

Isoindoline derivatives are disclosed, as for instance of the formula: ##STR1## and methods of preparation of these compounds, such as the reaction of o-cyano-benzylbromide with a compound of formula ##STR2## and subsequent saponification. The compounds possess analgesic and anti-inflammatory activity.

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Milan, Italy

Ada Buttinoni