Abbvie Deutschland Gmbh and Co Kg

Abbvie Inc.

Abbott Gmbh & Co Kg

Basf Aktiengesellschaft

Abbott Laboratories Corporation

Wood Innovations Ltd.

Other

Achim Moeller

Wilfried Hornberger

Andreas Kling

Helmut Mack

Martin Schmidt

Charles W Hutchins

Katja Jantos

Reinhold Mueller

Heinz Hillen

Wilfried Lubisch

Tariq Ghayur

Volker Nimmrich

Lothar Daum

Thomas Doerper

Sean Colm Turner

Michael Ochse

Mario Mezler

Bernhard K Mueller

Nicole Teusch

Franz Emling

Eve H Barlow

Hans-Joachim Danzer

Dietmar Seemann

Thomas Eckstein

Elizabeth Louise Van Der Kam

Axel Meyer

Kevin B Sippy

Frauke Pohlki

Ramin Faghih

Andreas R Striebinger

Gerhard Keilhauer

Carsten Krantz

Gerd Steiner

Udo Lange

Chung-Ming Hsieh

Anil Vasudevan

Karsten M Wicke

Michael Schulz

Thomas Subkowski

Gisela Backfisch

Jürgen Dinges

Karl-Heinz Geiss

Carrie Goodreau

Barbara Vogg

Juergen Delzer

Wolfgang Koerwer

Armin Beyerbach

Dieter Herr

Margaretha Bakker

Sahana Bose

Kurt Schellhaas

Christian Korn

Andreas Knauff

Jürgen Delzer

Dietmar Seeman

Johannes Graesser

Klaus Schollmeier

Hans-Georg LeMaire

A core layer suitable for a multilayer composite including at least one surface layer and one core layer, the surface layer arranged to at least partially cover the core layer and be fixedly connected thereto, wherein the core layer has elements composed of wood, which elements have plate-like regions arranged in zig-zag-shaped fashion, wherein a plate-like zig region of an element with an adjoining plate-like zag region of the element form a common edge between them, in such a way that the wood element of zig-zag-shaped form is formed, wherein elements of zig-zag-shaped form are arranged in the core layer such that two such edges of two different elements cross one another at a non-zero angle, and wherein the two elements are fixedly connected to one another at the crossing point. In one embodiment, a wood element of zig-zag-shaped form may be adhesively bonded to a planar wood element.

Core layer having wood elements, in particular wood elements having a corrugated structure

Compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R, Rand Rare as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by positive allosteric modulation of the &#x3b3;-aminobutyric acid B (GABA-B) receptor. Methods for making the compounds are described. Also described are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.

Substituted isoxazolopyridazinones and isothiazolopyridazinones and methods of use

The invention relates to neuromodulatory oligomers of the amyloid-&#x3b2;(1-42) protein, a particular production method, by means of which the oligomer can be obtained in a reproducible manner at high yield, the use of the oligomers as diagnostic and therapeutics agents, for the generation of oligomer-specific antibodies and for the discovery of substances which can interact with the oligomers and in the formation thereof. Corresponding methods for the production of the antibodies and for discovery of the substances are also disclosed as are the antibodies themselves and the use of the antibodies or substances as diagnostic and therapeutic agents. The invention further relates to derivatives of the oligomers and oligomers based on abbreviated forms of the amyloid-&#x3b2;(1-42) proteins, the production and use thereof.

Amyloid &#x3b2;(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof

The invention is related to a method and an apparatus () for the fabrication of an endless band () containing fiber material, in particular wood, comprising at least the following method steps: providing at least one fiber material block, the fiber material block having a face side; cutting off a plate element () from the face side of a fiber material block, the plate element () having a cutting surface from the fiber material block, a main surface facing the cutting surface, and an edge surface connecting the cutting surface and the main surface; arranging in relation to each other the cutting surface of the plate element () and a fiber material block such that the main surface of the plate element () follows the face surface of the fiber material block, wherein said face surface forms the main surface of a further plate element; connecting the plate element and the further plate element by a connecting means; cutting off the further plate element from the face side of the fiber material block. The invention is further related to the endless band () and the fiber material block, which is the source for the fabrication of the endless band ().

Method and apparatus for the fabrication of an endless band from a fiber material block, endless band and fiber material block

Compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R, R, R, R, Land Gare as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by positive allosteric modulation of the &#x3b3;-aminobutyric acid B (GABA-B) receptor. Methods for making the compounds are described. Also described are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.

Substituted pyrazolopyrimidines and method of use

The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind to the Nogo-66 receptor. Specifically, these antibodies have the ability to inhibit the binding of the natural ligand of the Nogo-66 receptor and neutralize the Nogo-66 receptor. These antibodies or portions thereof of the invention are useful for detecting NgR and for inhibiting NgR activity, for example in a human suffering from a disorder in which NgR or Nogo-66 activity is detrimental.

Neutralizing monoclonal antibodies against the Nogo-66 receptor (NgR) and uses thereof

The present invention relates to novel carboxamide compounds and their use as a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity and to a method for the therapeutic and/or prophylactic treatment by administering an effective amount of at least one of these carboxamide compounds. The carboxamide compounds are compounds of the general formula I in whichW&#x2014;Ris selected from and R, R, R, R, Y, Y, Y, Y, X, Q, m, k, Rand Rhave the meanings mentioned in the claims, the tautomers thereof and the pharmaceutically suitable salts thereof. Of these compounds those are preferred wherein Y, Y, Yand Yare CR, or one or two of the variables Yto Yare a nitrogen atom and the remaining variables are CR, wherein the radicals Rmay be identical or different and have the meanings mentioned in the claims.

Carboxamide compounds and their use as calpain inhibitors

The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity. The carboxamide compounds are compounds of the general formula I in which R, R, R, R, R, Q, Y, A and X have the meanings mentioned in the claims and the description, the tautomers thereof and the pharmaceutically suitable salts thereof. In particular, the compounds have the general formula Ia and Ib in which R, r, R, R, R, R, Y and X have the meanings mentioned in the claims, including the tautomers thereof and the pharmaceutically suitable salts thereof. Of these compounds those are preferred wherein Y is a moiety CH&#x2014;CH, CH&#x2014;CH&#x2014;CH, N(R)&#x2014;CH, N(R)&#x2014;CH&#x2014;CHor CH&#x2550;CH&#x2014;CH&#x2550;, each optionally having 1 or 2H-atoms replaced with identical or different radicals R, wherein Rand Rhave the meanings mentioned in the claims.

Amyloid beta(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof

The present invention relates to novel carboxamide compounds of the formula I and their use for the manufacture of a medicament. The carboxamide compounds are prodrugs of inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity.  

The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity. The carboxamide compounds are compounds of the general formula I in which R, R, R, R, W, Y and X have the meanings mentioned in the claims and the description, the tautomers thereof and the pharmaceutically suitable salts thereof. In particular, the compounds have the general formula I-A.a' and I-A.a&#x2033; in which m, E, R, R, R, R, R, Rand Rhave the meanings mentioned in the claims, n is 0, 1 or 2, the tautomers thereof and the pharmaceutically suitable salts thereof.

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Ludwigshafen, Germany

Achim Moeller