Bayer Aktiengesellschaft

Bayeraktiengesellschaft

Achim Hupperts

Reinhard Lantzsch

Manfred Jautelat

David T Erdman

Mark Wilhelm Drewes

Michael Ruther

Uwe Stelzer

Hermann Seifert

Karl Steinbeck

Method for production of a triazolinethione derivative

The invention relates to a process for preparing N-(5-amino-2-cyano-4-fluoro-phenyl)-sulphonamides in which, in a first step, 2-amino-4,5-difluoro-benzonitrile is reacted with sulphonyl halides in the presence of an acid acceptor and in the presence of a diluent at temperatures between 0&deg; C. and 150&deg; C. and, in a second step, the N-(2-cyano-4,5-difluoro-phenyl)-sulphonamides and/or N-(2-cyano-4,5-difluoro-phenyl)-sulphonimides obtained in the first step are as pure substances or as mixtures with ammonia in the presence of a diluent reacted at a temperature between 100&deg; C. and 200&deg; C. The invention furthermore relates to novel intermediates of the process.

Method for the production of N-(5-amino-2-cyano-4-fluoro-phenyl)-sulphonamides and new intermediate products

Method for production of 2,4,5-trifluoro-benzonitrile

Method for producing triazolinethione derivatives

Method for producing triazolinthion derivatives

The invention relates to a process for preparing N-(5-amino-2-cyano-4-fluoro-phenyl)-sulphonamides in which, in a first step, 2-amino-4,5-difluoro-benzonitrile is reacted with sulphonyl halides in the presence of an acid acceptor and in the presence of a diluent at temperatures between 0&deg; C. and 150&deg; C. and, in a second step, the N-(2-cyano-4,5-difluoro-phenyl)-sulphon-amides and/or N-(2-cyano-4,5-difluoro-phenyl)-sulphonamides obtained in the first step are as pure substances or as mixtures with ammonia in the presence of a diluent reacted at a temperature between 100&deg; C. and 200&deg; C. The invention furthermore relates to novel intermediates of the process.

According to a novel process, it is possible to prepare triazolinethione derivatives of the formula

The invention relates to a process for preparing N-(3-amino-4-fluoro-phenyl)-sulphonamides, N-(3-amino-4-fluoro-phenyl)-carboxamides or N-(3-amino-4-fluoro-phenyl)-carbamates of the general formula (I)

Method for producing N-(3-amino-4-fluoro-phenyl)-sulphonamides, N-(3-amino-4-fluoro-phenyl)-carboxylic acid amides and N-(3-amino-4-fluorophenyl) carbamates

The application describes a process for preparing 4-hydroxyanilines by the reaction of phenols with diazonium salts and subsequent reduction.

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Düsseldorf, Germany

Achim Hupperts