Bayer Schering Pharma Ag

Xention Limited

Achim Hermann

Klemens Lustig

Josef Pernerstorfer

Muneto Mogi

Heinrich Meier

Nicole Diedrichs

Masaomi Tajimi

Noriyuki Yamamoto

Hiroshi Fujishima

Axel Bouchon

Klaus Urbahns

Jean De Vry

Takeshi Yura

Yasuhiro Tsukimi

Hiroaki Yuasa

Jang Gupta

Fumihiko Hayashi

Elke Reiβmüller

Elke Reissmuller

Elke Reissmüller

Masaomi 1-8-17 Sakuragaoka Seika-Cho Tajimi

This invention relates to tetrahydro-quinolinylurea derivatives and salts thereof which are useful as active ingredients of pharmaceutical preparations. The tetrahydro-quinolinylurea derivative of the present invention has vanilloid receptor (VR1) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urological diseases or disorders, such as detrusor overactivity (overactive bladder), urinary incontinence, neurogenic detrusor overactivity (detrusor hyperflexia), idiopathic detrusor overactivity (detrusor instability), benign prostatic hyperplasia, and lower urinary tract symptoms; chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, and inflammatory disorders such as asthma and chronic obstructive pulmonary (or airways) disease (COPD).

Tetrahydro-quinolinylurea derivatives

This invention relates to a hydroxy-tetrahydro-naphthalene or an urea derivative formula (I) and salts thereof which are useful as active ingredients of pharmaceutical preparations, wherein A represents formula (II) or (III) wherein # represents the connection position to the molecule and Q, Q, Qand Qare defined, and E represents formula (IV) or (V) wherein # represents the connection position to the molecule and Q, Q, Q, Q, Q, R, na, ma, Xand Rare defined.

Tetrahydro-naphthalene and urea derivatives

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Düsseldorf, Germany

Achim Hermann