Hoffmann-la Roche Inc.

Merck Patent Gmbh

Curis, Inc.

Universitaet Regensburg

Achim Goepferich

Gerhard Winter

Kurt Lang

Markus Weigandt

Apollon Papadimitriou

Wolfgang Roedel

Senta Voss

Tobias Miller

Karin Kellner

Ulrike Leser-Reiff

Michaela Schultz

Torsten Blunk

Petra Bastian

Rainer Bader

Matthias Ferstl

Christoph Luschmann

The present invention relates to a novel process for the production of nanoparticles laden with active compounds and to the use thereof as medicaments. The process for the production of nanoparticles comprises the steps (a) dissolution of at least one active compound and at least one polymer in an organic solvent, (b) mixing of the solution prepared in step (a) with an aqueous phase, (c) evaporation of the organic solvent, (d) purification of the nanoparticles laden with active compound obtained in step (c) by means of dialysis against aqueous dialysis solution comprising the same active compound.

Process for producing nanoparticles laden with active ingredient

The subject-matter of the present invention are nanocomplexes of polyanions and cationic peptides which are, e.g., suitable for the transport of drugs into cells and their controlled release in the organism, as well as a complex material in which the nanocomplexes are bonded to a biologically active unit for the selective recognition of tissues, cells or organelles.

Polyanion nanocomplexes for therapeutic applications

The present invention makes available an optimal concentration of a hedgehog polypeptide for modulating growth and/or cartilage production by chondrocytes. The present invention allows for improvements in the culturing of chondrocytes to develop cartilaginous tissue ex vivo suitable for implantation to replace damaged or deteriorated cartilage in a patient.

Methods and reagents for tissue engineering of cartilage in vitro

The invention is concerned with a pharmaceutical preparation for subcutaneous, parenteral administration, which contains bisphosphonic acids or their salts as the active substance, as well as the production of this preparation. By means of the preparation in accordance with the invention it is possible to administer locally relatively high concentrations of bisphosphonates without the occurrence of incompatibilities.

Subcutaneous osteoporosis compositions

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Sinzing, Germany

Achim Goepferich