Merck Patent Gmbh

Achim Doerner

Lars Toleikis

Bjoern Hock

Ralf Guenther

Christine Knuehl

Laura Rhiel

Vanita D Sood

Carolin Sellmann

Simon Krah

Birgit Piater

A heterodimeric bispecific immunoglobulin molecule includes a first Fab or scFv fragment which specifically binds to EGFR, and a second Fab or scFv fragment which specifically binds to c-MET, and an antibody hinge region, an antibody CH2 domain and an antibody CH3 domain including a hybrid protein-protein interaction interface domain. Each of the interaction interface domains is formed by an amino acid segment of the CH3 domain of a first member and an amino acid segment of the CH3 domain of a second member. The hybrid protein-protein interface domain of the first chain is interacting with the protein-protein-interface of the second chain by homodimerization of a corresponding amino acid segment of the same member of the immunoglobulin superfamily within interaction domains.

Bi-specific antibodies for enhanced tumor selectivity and inhibition and uses thereof

Disclosed are bispecific aptamers binding with high specifity to a tumour specific antigen (TSA) and a effector cell specific antigen (ESA) for treatment of cancer.

Bispecific aptamers mediating tumour cell lysis

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Darmstadt, Germany

Achim Doerner