Akorn, Inc.

Taylor Pharmaceuticals

Akora, Inc.

Abu Alam

Robert W Flower

Elias Reichel

Ashok J Chavan

Dennis Roberts

Keith Glad

Brandon Busbee

Pablo J Diaz Cruz

Disclosed is a stable aqueous gel formulation suitable for topical use comprising water, an anesthetic (e.g., lidocaine hydrochloride), a viscoelastic polymer, and a tonicity modifier, wherein the aqueous gel formulation is free of preservatives and phosphate buffer, is isotonic with physiological fluids, and is sterile and has low particulate count. Also disclosed is a method of inducing topical anesthesia on a tissue or organ, e.g., the eye, of an animal comprising providing a stable aqueous gel formulation comprising water, an anesthetic, a viscoelastic polymer, and a tonicity modifier, wherein the aqueous gel formulation is free of preservatives and phosphate buffer, is isotonic with physiological fluids, and is sterile, and topically administering an effective amount of the aqueous gel formulation to the tissue or organ of the animal.

Aqueous gel formulation and method for inducing topical anesthesia

Aqueous indocyanine green (ICG) composition exhibiting enhanced stability, as well as enhanced ICG concentration, as compared to presently available ICG products. The composition comprises an aqueous ICG composition comprising ICG at a concentration of at least about 10 mg/ml and an aqueous diluent, wherein the composition is stable for at least 24 hours. Diagnostic and therapeutic methods for using these aqueous compositions are also contemplated, e.g., angiography, dye-enhanced photocoagulation, photodynamic therapy, for a variety of conditions, including Age-Related Macular Degeneration (ARMD), lesions and tumors.

Indocyanine green (ICG) compositions and related methods of use

Use of radiation-absorbing dyes (e.g., indocyanine green (ICG), fluorescein, rose bengal) and photodynamic dyes (e.g., hematoporphyrins, aminolevulinic acids, porphyrins, merocyanines, porphycenes, porfimer sodium, verteporfin, Photofrin II, PH-10, chlorins, zinc phthalocyanine, purpurins, pheophorbides, monoclonal antibody-dye conjugates of any of the foregoing dyes) for the treatment of conditions associated with abnormal vasculature, including, generally, lesions, and, more specifically, tumors (cancerous and benign) and choroidal neovascularization (CNV) associated with age-related macular degeneration (ARMD).

Methods for treating conditions and illnesses associated with abnormal vasculature

Methods concerning medical uses for fluorescent dyes, e.g., Indocyanine green (ICG), fluorescein, rose bengal, for diagnosis and treatment. Methods for enhancing the clarity of fluorescent dye angiograms using relatively high dye concentrations, methods for determining the direction of blood flow within a blood vessel using fluorescent dye angiograms, and methods of identifying blood vessels that feed a lesion, such as a CNV or tumor. Methods of reducing the flow of blood into lesions incorporating dye-enhanced photocoagulation are also provided.

Methods for diagnosing and treating conditions associated with abnormal vasculature using fluorescent dye angiography and dye-enhanced photocoagulation

An aqueous solution of droperidol suitable for injection having a concentration from about 0.1 to about 10.0 mg/ml, and a sufficient amount of tonicity adjusting agent to render the solution isotonic, the solution being in a sealed container. Also provided is an aqueous solution of droperidol suitable for injection, comprising droperidol at a concentration from about 2.75 to about 10 mg/ml, and the solution being in a sealed container.

Compositions and method for treating migraine

Oral dosage form of droperidol are provided and a method for treating migraine using such oral formulations. The dosage forms include tablets, capsules, powders, effervescent formulations and syrups.

Oral droperidol compositions and method for treating migraine

Sublingual and buccal dosage forms of droperidol are provided in a method for treating migraine using such formulations.

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Lake Forest, IL, United States of America

Abu Alam