Acell, Inc.

Cook Biotech, Inc.

Incumed, Inc.

Alfred E. Mann Foundation for Scientific Research

Incumed Llc, a Nevada Limited Liability Co.

Medical Research Products-b, Inc.

Abram D Janis

Clay D Fette

Benjamin T Kibalo

Katherine A Stuart

Kimberly Kentner

Byron L Moran

Claude A Vidal

Christopher H Porter

Paul Kaluzniak

Russ J Redmond

Russell J Redmond

Alfred E Mann

Michael C Hiles

Kelly Ann Chapman

Jason P Hodde

Andrew O Brightman

Kimberly A Kentner

The present invention is directed to methods of manufacturing bioactive gels from ECM material, i.e., gels which retain bioactivity, and can serve as scaffolds for preclinical and clinical tissue engineering and regenerative medicine approaches to tissue reconstruction. The manufacturing methods take advantage of a new recognition that bioactive gels from ECM material can be created by digesting particularized ECM material in an alkaline environment and neutralizing to provide bioactive gels.

Methods of manufacturing bioactive gels from extracellular matrix material

A hemostatic device, method of making, and method of using for internal and external applications to wounds in the body of a patient to induce homeostasis at an anatomical site.

Hemostatic device

A hemostatic device, method of making, and method of using for internal and external applications to wounds in the body of a patient to induce hemostasis at an anatomical site.

Described, in certain aspects of the invention, are multilaminate medical graft products, as well as methods for preparing and using the same. An illustrative multilaminate medical graft product of the invention comprises a first layer of remodelable extracellular matrix (ECM) material bonded to a second layer of remodelable ECM material, wherein the first material layer is enriched with a growth factor relative to the second material layer. Such a remodelable ECM material may be comprised of submucosa from a warm-blooded vertebrate, for example, porcine small intestinal submucosa (SIS).

Graft materials and methods for staged delivery of bioactive components

A method and apparatus for reducing the incident of infection proximate to an exit site where a prosthesis fastener, e.g., a bone screw, percutaneously penetrates a patient's skin/soft tissue. Infection reduction is achieved in accordance with the invention by growing a tissue integrating seal around the fastener proximate to the exit site.

Prosthesis attachment method and apparatus with soft tissue integrating seal

Described are tissue graft constructs that include submucosa and other extracellular matrix materials that incorporate a number of exogenous proteins. Further described are methods for making tissue graft constructs that include stripping endogenous heparin binding proteins from a porcine graft material and thereafter binding one or more human growth factors to the native heparin molecules that are retained within the graft material. Such graft materials may be used in methods for the treatment of wounds in patients.

Growth factor modified extracellular matrix material preparation and methods for preparation and use thereof

A medical apparatus and method of use for implanting a percutaneous catheter in a patient's body which catheter can be easily positioned, repositioned, and replaced. The apparatus includes an elongate sleeve having a tapered forward portion to facilitate its insertion through an undersized incision. The sleeve provides an interior elongate passageway which extends from a sleeve proximal end to a sleeve distal end. The sleeve is intended to be percutaneously implanted through an incision in the patient's skin so that the sleeve distal end resides subcutaneously. The sleeve outer peripheral surface carries a layer of porous material intended to be placed under the patient's outer skin layer in contact with the dermis to promote tissue ingrowth for anchoring the sleeve and forming an infection resistant barrier. The sleeve passageway is dimensioned to snugly accommodate the outer surface of catheter while permitting the catheter to slide relative to the sleeve. A sealing device is mounted around the catheter adjacent to the sleeve proximal end to prevent deleterious material from migrating into the patient's body along the catheter outer surface. A locking member secured to the sleeve can be pivoted to an unlocked portion for permitting axial and rotational movement of said catheter relative to said sleeve and or to a locked position for preventing such relative movement.

Enhanced apparatus for percutaneous catheter implantation and replacement

Growing community of inventors

Columbia, MD, United States of America

Abram D Janis