Bromine Compounds Limited

Products Chimiques Auxiliaires Et De Synthese

Abram Becker

Hyman Stollar

Nurit Kornberg

Jean-Marie Schneider

Ariel A Ewenson

Bertha Croitoru

Hayman Stollar

Jean-Yves Lenoir

Berta Croitoru

Gérard Guillamot

Valéry Dambrin

Michel Follet

A subject matter of the present invention is novel intermediates for the synthesis of (R)-tamsulosin and of its pharmaceutically acceptable salts, and also the associated preparation process.

Intermediates for the synthesis of (R)-tamsulosin and of its pharmaceutically acceptable salts and process for their preparation

In a process for the preparation and the isolation of p-hydroxybenzonitrile (HBN), in which a p-halogenated phenol is reacted with cuprous cyanide in a suitable solvent, the reaction mixture obtained after the reaction of the p-halogenated phenol with cuprous cyanide has been substantially completed is contacted with an aqueous solution of a bromide salt and, optionally, an organic diluent, the aqueous and organic phases are separated, HBN is distilled out from the organic phase, an alkali metal cyanide is added to the aqueous phase and CuCN is filtered off from the resulting aqueous phase.

Process for the preparation of HBN

Biaryl derivatives are produced by coupling an aryl halide in an aqueous alkaline solution in the presence of a palladium catalyst, using formic hydrazide as the reducing agent.

Method of production of biaryl derivatives

Process for the preparation and isolation of HBN

A process is provided by means of which aromatic nitriles can be isolated in high yield. The process comprises reacting an aromatic halogenated compound with cuprous cyanide in a suitable solvent. The process is suitable for preparing many important materials, such as p-hydroxybenzonitrile.

Process for the preparation and the isolation of aromatic nitriles

A process is described which permits to prepare substantially pure 2-tert-butyl-4-methoxyphenol, by reacting 4-bromo-2-tert-butylphenol with a methoxide in an organic solvent. The process permits to obtain a substantially pure 2-isomer, and avoids the need for the separation of the 2- and 3-isomers.

Process for preparing 2-tert-butyl-4-methoxyphenol

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Paris, France

Abram Becker