Wockhardt Limited

Abraham Thomas

Mahesh Vithalbhai Patel

Noel John De Souza

Nitin Shetty

Dilip J Upadhyay

Shivkumar Agarwal

Nishith Chandra Chaturvedi

Habil Fakhruddin Khorakiwala

Sreenivas Kandepu

The present invention relates to optically pure S-(&#x2212;)-benzoquinolizine carboxylic acids, their derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof, substantially free of their R-(+)-isomers, to processes for preparation of the optically pure S-(&#x2212;)-benzoquinolizine carboxylic acids, their derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof substantially free of their R-(+)-isomers, and to pharmaceutical compositions comprising the S(&#x2212;)-benzoquinolizine carboxylic acids, their derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof.

Antibacterial optically pure benzoquinolizine carboxylic acids, processes, compositions and methods of treatment

The present invention relates to optically pure S-(&minus;)-benzoquinolizine carboxylic acids, their derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof, substantially free of their R-(&plus;)-isomers, to processes for preparation of the optically pure S-(&minus;)-benzoquinolizine carboxylic acids, their derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof substantially free of their R-(&plus;)-isomers, and to pharmaceutical compositions comprising the S(&minus;)-benzoquinolizine carboxylic acids, their derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof. These compounds and compositions can be used to systemically and topically treat bacterial Gram-positive, Gram-negative and anaerobic infections, specially resistant Gram-positive organism infections, Gram-negative organism infections, mycobacterial infections and emerging nosocomial pathogen infections, while avoiding toxic effects associated with the administration of the racemic mixture of RS-(&plusmn;)-benzoquinolizine carboxylic acid. The compounds and compositions of this invention can also be used to treat diseases and disorders caused by Gram-positive, Gram-negative and anaerobic bacteria, and diseases and disorders caused by resistant Gram-positive organisms, Gram-negative organisms, mycobacteria and nosocomial pathogens.

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Aurangabad, India

Abraham Thomas