Yeda Research and Develpment & Co. Ltd

Other

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Yeda Research and Development Ltd.

Abraham Shanzer

Jacqueline Libman

Irit Sagi

Tamar Danon

Rina Arad-Yellin

Netta Sela

Raghavendra Kikkeri

Shneior Lifson

Ron Naaman

David Ferdinand Cahen

Abraham Warshawsky

Yoram Shechter

Michal Neeman

Amos Breskin

Rachel Chechik

Bilha Schechter

Israel Rubinstein

Konstantin Gartsman

Jacob Sagiv

Ioav Zvi Cabantchik

David Samuel

Alexander Kadyshevitch

Zvi Paltiel

Suzi Steinberg

Yitzhak Tor

Eduard Schwartz

An antibody comprising an antigen recognition region which comprises CDR amino acid sequences set forth in SEQ ID NO: 7, 8, 9, 10, 11 and 12.

Antibodies and pharmaceutical compositions containing same useful for inhibiting activity of metalloproteins

The present invention relates to a compound having the general Formula (I): 

A delivery system and method for targeting a contrast agent to tissues and organs for improved diagnosis of tumors and for prognosis and follow-up of cancer therapy by X-ray imaging. The delivery system includes a conjugate or complex of a macromolecular carrier and a contrast agent selected from the group consisting of: (a) a compound having a heavy element with an atomic number in the range of 75 to 92, and (b) a compound having an element with a property of an abrupt change in its X-ray attenuation coefficient within the energy range used for radiography, said macromolecular carrier of said conjugate or complex being optionally linked to a specific tissue marker molecule.

X-ray imaging of tumors with dextran carrier of platinum compounds

A hybrid organic-inorganic semiconductor device is provided as a sensor for chemicals and light, said device being composed of: (i) at least one layer of a conducting semiconductor such as doped n-GaAs or n-(Al,Ga)As; (ii) at least one insulating layer such as of an undoped semiconductor; e.g. GaAs or (Al,Ga)As; (iii) a thin layer of multifunctional organic sensing molecules directly chemisorbed on one of its surfaces, said multifunctional organic sensing molecules having at least one functional group that binds to said surface and at least one another functional group that serves as a sensor; and (iv) two conducting pads on the top layer making electrical contact with the electrically conducting layer, so that the electrical current can flow between them at a finite distance from the surface of the device. The surface-binding functional group of the multifunctional organic sensing molecule may be one or more aliphatic or aromatic carboxyl, thiol, sulfide, hydroxamic acid or trichlorosilane groups. The functional group that serves as a sensor may be a group suitable for binding and detection of metal ions such as Cu , Fe and Ru such as radicals derived from hydroxamic acids, bipyridyl, imidazol and hydroxyquinoline, or a group that is an efficient light absorber at a given wavelength and is suitable for detection of light such as radicals derived from aliphatic or aromatic hydroxamates, substituted aromatic groups such as cyanobenzoyl and methoxybenzoyl, bipyridyl, hydroxyquinoline, or imidazolyl groups to which a metal porphyrin or a metal phtalocyanin residue is attached.

Hybrid organic-inorganic semiconductor structures and sensors based thereon

Pharmaceutical compositions comprising hydroxamate derivatives for iron

Vanadyl complexes of hydroxamate chelators and pharmaceutical

There are provided novel compounds useful as selective extractants of metal values from aqueous systems comprising a plurality of such ionic species. There is further provided a process for the production of the novel compounds. The invention also relates to a process of selective metal extraction by means of the novel compounds of the invention.

Extractants for the separation of transition and related metal ions

Ligand compounds useful as extractants of certain metals from solutions. Effective also as promoters of the growth of microorganisms. A process for the preparation of such hexadentate ligands and methods of selective extraction of transition and related metal ions from admixtures with other metals.

Trishydroxamic acids

According to the invention organic monolayer films are applied to an electrically conductive substrate, resulting in an electrode which can be used in electrochemical processes. The said film serves as ultrathin membrane and allows certain selected species to approach the substrate and be detected. The film comprises active species which are selective towards specific species contained in mixture with others and a blocking surface sealing component. It is also possible to use one compound serving both purposes. The components of the film are attached to the substrate by a variety of means: adsorption, chemisorption, electro-chemical deposition.

Ionic recognition and selective response in self assembling monolayer

The present inveniton relates to novel lithium ionophores, to a process for producing such lithium ionophores and to their uses as pharmaceutical compositions, electrodes and as components of batteries.

Lipophilic lithium ionophores

There are provided novel enterobactin type compounds. There is provided a novel process for the production of enterobactin, and of novel enterobactin type compounds which process is based on the reaction of a serine derivative with a stannoxane of the [BU.sub.2 Sn(OCH.sub.2 CH.sub.2 O)] type. Enterobactin is a known compound of known utility. The novel derivatives are valuable as sequestering agents for iron and other transition metals, for the separation and analysis of same. They can be used as active ingredients in pharmaceutical compositions for the removal of such metals accumulated above an acceptable level in patients.

Enterobactin type compounds

The present invention relates to novel macrocyclic carbonyl compounds of the macrocyclic carbamate and lactone type, to chiral macrocyclic structures, to macrocyclic urea compounds and to macrocyclic thiolactones and to a process for the preparation of same. The process of the invention comprises reacting a stannoxane, silazane or silathiane compound with an activated carbonyl compound in an organic solvent at moderate temperature.

Some macrocyclic compounds and their preparation

Growing community of inventors

Rehovot, Israel

Abraham Shanzer